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Merck

T9531

Sigma-Aldrich

D-(+)-Trehalose dihydrate

≥99% (HPLC), from Saccharomyces cerevisiae

Synonim(y):

Trehalose dihydrate, α,α-Trehalose, α-D-Glucopyranosyl-α-D-glucopyranoside

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About This Item

Wzór empiryczny (zapis Hilla):
C12H22O11 · 2H2O
Numer CAS:
Masa cząsteczkowa:
378.33
Beilstein:
5322018
Numer WE:
Numer MDL:
Kod UNSPSC:
12352201
Identyfikator substancji w PubChem:
NACRES:
NA.25

pochodzenie biologiczne

Saccharomyces cerevisiae

Poziom jakości

Próba

≥99% (HPLC)

Formularz

powder

aktywność optyczna

[α]20/D 174 to 182 °, c = 7% (w/v) in water

metody

HPLC: suitable
PCR: suitable
cell based assay: suitable
cryopreservation: suitable

zanieczyszczenia

≤5.0% EtOH
<20 ppm Trace metals

kolor

white

mp

97-99  °C

rozpuszczalność

water: 50 mg/mL, clear, colorless

Zastosowanie

advanced drug delivery
agriculture
cell analysis
life science and biopharma
sample preparation

temp. przechowywania

room temp

ciąg SMILES

[H]O[H].[H]O[H].OC[C@H]1O[C@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C12H22O11.2H2O/c13-1-3-5(15)7(17)9(19)11(21-3)23-12-10(20)8(18)6(16)4(2-14)22-12;;/h3-20H,1-2H2;2*1H2/t3-,4-,5-,6-,7+,8+,9-,10-,11-,12-;;/m1../s1

Klucz InChI

DPVHGFAJLZWDOC-PVXXTIHASA-N

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Opis ogólny

Trehalose, also known as mycose or tremalose, is a nonreducing disaccharide of glucose commonly found in fungi, bacteria, and invertebrates. Its presence in these organisms highlights its significance in various biological processes and potential applications in biochemical research and cell culture studies.

Zastosowanie

D-(+)-Trehalose dihydrate has been used:

  • as a transcription factor EB (TFEB) to study its effects on an autophagy-lysosomal system in human silicosis alveolar macrophages
  • as stabilizing excipient in spray-dried protein formulations
  • as a cryoprotectant to study its effects on mouse testicular cell suspensions

Działania biochem./fizjol.

D-(+)-Trehalose shows anti-desiccant and cryopreservative activities. It acts as an osmolyte, and stress protectant and helps in the storage and transport of carbon. Trehalose is involved in the food, cosmetic, and pharmaceutical industries. It plays a vital role in the survival of certain insects and plants known as anhydrobionts during harsh environments such as high rates of dehydration.

Jakość

Reduced metal ion content.

Uwaga dotycząca przygotowania

Prepared by ion exchange chromatography.

Inne uwagi

For additional information on our range of Biochemicals, please complete this form.
To gain a comprehensive understanding of our extensive range of Disaccharides for your research, we encourage you to visit our Carbohydrates Category page.
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Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 1

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

Eyeshields, Gloves, type N95 (US)


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Odwiedź Bibliotekę dokumentów

Michael Peitz et al.
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This protocol describes a highly standardized pipeline for transcription factor-mediated forward programming of human pluripotent stem cells into highly enriched glutamatergic or GABAergic neurons followed by a cryopreservation step that enables the generation of large quality-controlled batches. This approach is particularly
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Nicolas Barbezier et al.
EMBO molecular medicine, 3(1), 35-49 (2011-01-05)
Oculopharyngeal muscular dystrophy (OPMD) is an adult-onset syndrome characterized by progressive degeneration of specific muscles. OPMD is caused by extension of a polyalanine tract in poly(A) binding protein nuclear 1 (PABPN1). Insoluble nuclear inclusions form in diseased muscles. We have
Sebastian Sorge et al.
Cell reports, 31(7), 107659-107659 (2020-05-21)
The mitochondrial electron transport chain (ETC) enables essential metabolic reactions; nonetheless, the cellular responses to defects in mitochondria and the modulation of signaling pathway outputs are not understood. We show that Notch signaling and ETC attenuation via knockdown of COX7a
Alan Twomey et al.
International journal of pharmaceutics, 487(1-2), 91-100 (2015-04-19)
In frozen and lyophilized systems, the biological to be stabilized (e.g. therapeutic protein, biomarker, drug-delivery vesicle) and the cryo-/lyo-protectant should be co-localized for successful stabilization. During freezing and drying, many factors cause physical separation of the biological from the cryo-/lyo-protectant

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