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H3911

SAFC

L-Histidine

Produkcja farmaceutyczna

Synonim(y):

(S)-2-Amino-3-(4-imidazolyl)propionic acid, NSC 137773

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About This Item

Wzór empiryczny (zapis Hilla):
C6H9N3O2
Numer CAS:
71-00-1
Masa cząsteczkowa:
155.15
Beilstein:
84088
Numer WE:
200-745-3
Numer MDL:
MFCD00064315
Kod UNSPSC:
12352209
eCl@ss:
32160406
NACRES:
NA.26

pochodzenie biologiczne

non-animal source

Poziom jakości

400

Próba

≥98.5%

Postać

crystalline powder

metody

cell culture | mammalian: suitable

zanieczyszczenia

endotoxin, heavy metals, trace metals, residual solvents, tested

mp

282 °C (dec.) (lit.)

rozpuszczalność

H2O: 50 mg/mL

przydatność

suitable for manufacturing use

Zastosowanie

pharmaceutical (small molecule)

obecność zanieczyszczeń

cytotoxicity, tested

ciąg SMILES

N[C@@H](Cc1c[nH]cn1)C(O)=O

InChI

1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1

Klucz InChI

HNDVDQJCIGZPNO-YFKPBYRVSA-N

informacje o genach

human ... CA1(759) , CA2(760)

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Opis ogólny

Our SAFC® portfolio of high-quality raw materials for use in biopharmaceutical processing withstands strict quality control procedures plus the documentation and expertise to help our customers meet requirements as defined by the M-Clarity Program.

M-Clarity Program

Our comprehensive portfolio of upstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Trust us to deliver supply chain transparency and reliable sourcing around the globe, streamlining your product qualification with best-in-class regulatory support and service.
To request documentation for this product, please contact Customer Support and select ‘Product Documentation′. Please note that access to the documentation for this product requires a confidentiality disclosure agreement.

Zastosowanie

L-Histitidine is an essential amino acid. It is used as a cell culture media component for the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies.

Działania biochem./fizjol.

Precursor of histamine by action of histidine decarboxylase.

Informacje prawne

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany
This page may contain text that has been machine translated.

Zastosowanie

Numer produktu
Opis
Cennik

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 1

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

Eyeshields, Gloves, type N95 (US)

Certyfikaty analizy (CoA)

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Shweta Singh et al.
Microbial cell factories, 7, 28-28 (2008-10-14)
The large-scale production of G-protein coupled receptors (GPCRs) for functional and structural studies remains a challenge. Recent successes have been made in the expression of a range of GPCRs using Pichia pastoris as an expression host. P. pastoris has a
Urszula Kosinska Eriksson et al.
Science (New York, N.Y.), 340(6138), 1346-1349 (2013-06-15)
Aquaporins are membrane channels that facilitate the flow of water across biological membranes. Two conserved regions are central for selective function: the dual asparagine-proline-alanine (NPA) aquaporin signature motif and the aromatic and arginine selectivity filter (SF). Here, we present the
Camilla Hofström et al.
Journal of medicinal chemistry, 56(12), 4966-4974 (2013-05-23)
Engineered affibody molecules can be used for high contrast in vivo molecular imaging. Extending a recombinantly produced HER2 binding affibody molecule with a hexa-histidine tag allows for convenient purification by immobilized metal-ion affinity chromatography and labeling with [(99m)Tc(CO)3](+) but increases
Pawel Swietach et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(22), E2064-E2073 (2013-05-17)
Ca(2+) signaling regulates cell function. This is subject to modulation by H(+) ions that are universal end-products of metabolism. Due to slow diffusion and common buffers, changes in cytoplasmic [Ca(2+)] ([Ca(2+)]i) or [H(+)] ([H(+)]i) can become compartmentalized, leading potentially to
H M Golder et al.
Journal of dairy science, 97(8), 5131-5150 (2014-06-03)
Ruminal bacterial community composition (BCC) and its associations with ruminal fermentation measures were studied in dairy heifers challenged with combinations of grain, fructose, and histidine in a partial factorial study. Holstein-Friesian heifers (n=30) were randomly allocated to 5 triticale grain-based
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Chromatograms

application for HPLC

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