1.04352

L-Histidine

EMPROVE^® EXPERT, Ph. Eur., ChP, JP, USP

• Synonim(y): His, (S)-2-Amino-3-(4-imidazolyl)propionic acid, NSC 137773
• Wzór empiryczny (zapis Hilla): C₆H₉N₃O₂
• Numer CAS: 71-00-1
• Masa cząsteczkowa: 155.15
• Beilstein: 84088
• Numer MDL: MFCD00064315
• Kod UNSPSC: 12352209
• Numer indeksu EC: 200-745-3

Właściwości

• agency: ChP; JP; Ph. Eur.; USP
• Poziom jakości: 500
• linia produktu: EMPROVE^® EXPERT
• Postać: solid
• metody: API processing | cocrystal formation: suitable
• pH: 7.7 (20 °C, 10 g/L in H₂O)
• mp: 282 °C (dec.) (lit.)
• Zastosowanie: liquid formulation; parenterals; pharma/biopharma processes; pharmaceutical
• temp. przechowywania: 2-30°C
• ciąg SMILES: N[C@@H](Cc1c[nH]cn1)C(O)=O
• InChI: 1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1
• Klucz InChI: HNDVDQJCIGZPNO-YFKPBYRVSA-N

Opis

Opis ogólny

Chemicals play an important role in the stabilization of a biologic drug during its manufacturing and formulation process – for instance, by preventing aggregation. We offer a wide range of high-quality stabilizers, buffers and salts to successfully purify and formulate your biomolecules. Specifically developed for high-risk applications, they are low in bioburden and endotoxins.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Zastosowanie

Histidine is used in biopharma manufacturing as a buffer in formulation. It is often used together with histidine monohydrochloride to prepare histidine buffer with the desired pH value.
Due to its low microbial and endotoxin limits, L-Histidine Emprove^® Expert is especially suitable for high-risk applications.

Działania biochem./fizjol.

Precursor of histamine by action of histidine decarboxylase.

Informacje prawne

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable