1.04354

L-Histidine monohydrochloride monohydrate

EMPROVE^® EXPERT, Ph. Eur., BP, ChP, JP

• Synonim(y): His, L-α-Amino-β-(4-imidazolyl)propionic acid monohydrochloride
• Wzór empiryczny (zapis Hilla): C₆H₉N₃O₂ · HCl · H₂O
• Numer CAS: 5934-29-2
• Masa cząsteczkowa: 209.63
• Beilstein: 4168261
• Numer MDL: MFCD00151027
• Kod UNSPSC: 12352107
• Numer indeksu EC: 211-438-9

Właściwości

• agency: BP; ChP; JP; Ph. Eur.
• Poziom jakości: 500
• ciśnienie pary: <1 hPa ( 20 °C)
• linia produktu: EMPROVE^® EXPERT
• Próba: 98.5-101.0% (alkalimetric); 99.0-101.0% (perchloric acid titration)
• Postać: solid
• pH: 3.5-4.5 (20 °C, 100 g/L in H₂O)
• mp: 254 °C (dec.) (lit.)
• rozpuszczalność: 149.55 g/L
• gęstość: 1.49 g/cm³ at 20 °C
• Zastosowanie: liquid formulation; parenterals; pharma/biopharma processes; pharmaceutical
• temp. przechowywania: 2-30°C
• ciąg SMILES: O.Cl.N[C@@H](Cc1c[nH]cn1)C(O)=O
• InChI: 1S/C6H9N3O2.ClH.H2O/c7-5(6(10)11)1-4-2-8-3-9-4;;/h2-3,5H,1,7H2,(H,8,9)(H,10,11);1H;1H2/t5-;;/m0../s1
• Klucz InChI: CMXXUDSWGMGYLZ-XRIGFGBMSA-N

Opis

Opis ogólny

Chemicals play an important role in the stabilization of a biologic drug during its manufacturing and formulation process – for instance, by preventing aggregation. We offer a wide range of high-quality stabilizers, buffers and salts to successfully purify and formulate your biomolecules. Specifically developed for high-risk applications, they are low in bioburden and endotoxins.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Zastosowanie

Histidine monohydrochloride is used in biopharmaceutical manufacturing as a buffer in formulation. It is often used along with histidine to prepare histidine buffer with the desired pH value.
Due to its low microbial and endotoxin limits, L-Histidine monohydrochloride monohydrate Emprove^® Expert is especially suitable for high-risk applications.

Informacje prawne

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable