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G6793

Sigma-Aldrich

GW7647

≥98% (HPLC)

Synonim(y):

2-(4-(2-(1-Cyclohexanebutyl)-3-cyclohexylureido)ethyl)­phenyl­thio)-2-methyl­propionic acid

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About This Item

Wzór empiryczny (zapis Hilla):
C29H46N2O3S
Numer CAS:
265129-71-3
Masa cząsteczkowa:
502.75
Numer MDL:
MFCD06798379
Kod UNSPSC:
12352200
Identyfikator substancji w PubChem:
24278790
NACRES:
NA.77

Próba

≥98% (HPLC)

kolor

white

rozpuszczalność

DMSO: soluble 16 mg/mL
H2O: insoluble

ciąg SMILES

CC(C)(Sc1ccc(CCN(CCCCC2CCCCC2)C(=O)NC3CCCCC3)cc1)C(O)=O

InChI

1S/C29H46N2O3S/c1-29(2,27(32)33)35-26-18-16-24(17-19-26)20-22-31(28(34)30-25-14-7-4-8-15-25)21-10-9-13-23-11-5-3-6-12-23/h16-19,23,25H,3-15,20-22H2,1-2H3,(H,30,34)(H,32,33)

Klucz InChI

PKNYXWMTHFMHKD-UHFFFAOYSA-N

informacje o genach

human ... PPARA(5465)

Zastosowanie

GW7647 has been used as a peroxisome proliferator-activated receptor α (PPAR α) ligand:
  • in defatting medium to treat primary human hepatocytes
  • to test its effect on the glycolytic function in cardiomyocytes
  • to test its effect on infant mouse heart
  • in breast cancer MDA-MB-231 cells to activate PPARs

Działania biochem./fizjol.

GW7647 reduces serum triglyceride levels and enhances hepatic expression of genes associated with β-oxidation. Usage of GW7647 along with metformin in conditions of liver steatosis or injury improves the enzymatic levels of aspartate transaminase (AST) and alanine transaminase (ALT) in serum.
Potent human PPARα agonist. Use to study the biology of PPARα receptor in human cells.

Cechy i korzyści

This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informacje prawne

Sold for research purposes only under agreement from Glaxo­Smith­Kline
This page may contain text that has been machine translated.

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

Eyeshields, Gloves, type N95 (US)

Certyfikaty analizy (CoA)

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GW1929 hydrate >98% (HPLC), solid

Sigma-Aldrich

G5668

GW1929 hydrate

Rosiglitazone ≥98% (HPLC)

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R2408

Rosiglitazone

GW501516 ≥98% (HPLC)

Sigma-Aldrich

SML1491

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GW3965 hydrochloride ≥98% (HPLC), powder

Sigma-Aldrich

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Leukotriene B4 ~100 μg/mL in ethanol, ≥97%

Sigma-Aldrich

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Leukotriene B4

Palmitoylethanolamide

Sigma-Aldrich

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Palmitoylethanolamide

Bezafibrate ≥98%, solid

Sigma-Aldrich

B7273

Bezafibrate

Jun Zhang et al.
Oncotarget, 8(13), 20766-20783 (2017-02-12)
Peroxisome proliferators-activated receptors (PPARα, γ and δ) are potentially effective targets for Type 2 diabetes mellitus therapy. The severe effects of known glitazones and the successfully approved agents (saroglitazar and lobeglitazone) motivated us to study novelly potent PPARs drugs with
Sriram Ramanan et al.
Free radical biology & medicine, 45(12), 1695-1704 (2008-10-15)
Whole-brain irradiation (WBI) can lead to cognitive impairment several months to years after irradiation. Studies on rodents have shown a rapid and sustained increase in activated microglia (brain macrophages) following brain irradiation, contributing to a chronic inflammatory response and a
Yanjie Cheng et al.
Molecular therapy. Nucleic acids, 9, 195-206 (2017-12-17)
Widely varied compounds, including certain plasticizers, hypolipidemic drugs (e.g., ciprofibrate, fenofibrate, WY-14643, and clofibrate), agrochemicals, and environmental pollutants, are peroxisome proliferators (PPs). Appropriate dose of PPs causes a moderate increase in the number and size of peroxisomes and the expression
Yeon-Ji Kim et al.
Food research international (Ottawa, Ont.), 101, 209-217 (2017-09-25)
Chronic alcohol consumption leads to hepatic lipid accumulation and alcoholic fatty liver disease. Previously, we demonstrated that barley sprout extract, which contains saponarin as an active compound, reduces hepatic steatosis. In this study, we investigated the effect of barley sprout
Anne Mazzucotelli et al.
Diabetes, 56(10), 2467-2475 (2007-07-25)
The purpose of this work was to determine the pattern of genes regulated by peroxisome proliferator-activated receptor (PPAR) gamma coactivator 1 alpha (PGC-1 alpha) in human adipocytes and the involvement of PPARalpha and PPARgamma in PGC-1 alpha transcriptional action. Primary
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