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D8440
15-Deoxy-Δ12,14-prostaglandin J2
≥95% (HPLC), 1 mg/mL in methyl acetate
Synonim(y):
11-Oxoprosta-(5Z,9,12E,14E)-tetraen-1-oic acid, 15-Deoxy-Δ12,14-PGJ2
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About This Item
Wzór empiryczny (zapis Hilla):
C20H28O3
Numer CAS:
Masa cząsteczkowa:
316.43
Numer WE:
Numer MDL:
Kod UNSPSC:
12352211
Identyfikator substancji w PubChem:
NACRES:
NA.77
Polecane produkty
Poziom jakości
Próba
≥95% (HPLC)
Formularz
liquid
stężenie
1 mg/mL in methyl acetate
Warunki transportu
wet ice
temp. przechowywania
−20°C
ciąg SMILES
CCCCC\C=C\C=C1/[C@@H](C\C=C/CCCC(O)=O)C=CC1=O
InChI
1S/C20H28O3/c1-2-3-4-5-6-10-13-18-17(15-16-19(18)21)12-9-7-8-11-14-20(22)23/h6-7,9-10,13,15-17H,2-5,8,11-12,14H2,1H3,(H,22,23)/b9-7-,10-6+,18-13+/t17-/m0/s1
Klucz InChI
VHRUMKCAEVRUBK-GODQJPCRSA-N
Opis ogólny
15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) is a prostaglandin J2 (PGJ2) metabolite and a naturally occurring derivative of prostaglandin D2. It is produced during inflammatory processes.
Zastosowanie
15-Deoxy-Δ12,14-prostaglandin J2 has been used:
- to study its effect on lipid accumulation, viability/mitochondrial activity, and amount of vasculature in vascularized adipose tissue model
- as a peroxisome proliferator-activated receptor (PPARγ) agonist to activate intestinal fatty acid binding protein (I-FABP)-PPARγ pathway
- as a supplement in culture medium for induced neural stem/progenitor cells (NSPCs) differentiation
Działania biochem./fizjol.
15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) regulates inflammatory response in vivo. 15d-PGJ2 also elicits PPARγ-independent inhibition of nuclear factor (NF)-κB dependent transcription. It acts as an anti-angiogenic factor and triggers endothelial cell apoptosis.
Selective agonist to PPARγ (peroxisome proliferator-activated receptors). Inhibits the proliferation of cancer cell lines that express PPARγ and cyclooxygenase-2 (COX-2).
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Hasło ostrzegawcze
Danger
Zwroty wskazujące rodzaj zagrożenia
Zwroty wskazujące środki ostrożności
Klasyfikacja zagrożeń
Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
Organy docelowe
Central nervous system
Zagrożenia dodatkowe
Kod klasy składowania
3 - Flammable liquids
Klasa zagrożenia wodnego (WGK)
WGK 2
Temperatura zapłonu (°F)
15.8 °F - closed cup
Temperatura zapłonu (°C)
-9 °C - closed cup
Środki ochrony indywidualnej
Eyeshields, Faceshields, Gloves
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