D5446

7,8-Dihydroxyflavone hydrate

≥98% (HPLC)

• Wzór empiryczny (zapis Hilla): C₁₅H₁₀O₄ · xH₂O
• Numer CAS: 38183-03-8
• Masa cząsteczkowa: 254.24 (anhydrous basis)
• Numer WE: 253-812-4
• Numer MDL: MFCD00006836
• Kod UNSPSC: 12352200
• Identyfikator substancji w PubChem: 329798806
• NACRES: NA.77

Właściwości

• Próba: ≥98% (HPLC)
• Postać: solid
• warunki przechowywania: desiccated
• rozpuszczalność: DMSO: 24 mg/mL
• temp. przechowywania: room temp
• ciąg SMILES: Oc1ccc2C(=O)C=C(Oc2c1O)c3ccccc3
• InChI: 1S/C15H10O4/c16-11-7-6-10-12(17)8-13(19-15(10)14(11)18)9-4-2-1-3-5-9/h1-8,16,18H
• Klucz InChI: COCYGNDCWFKTMF-UHFFFAOYSA-N

Opis

Zastosowanie

7,8-Dihydroxyflavone hydrate has been used as tropomyosin-receptor-kinase B (TrkB) agonist in mice and to inhibit TrkB for monitoring evoked excitatory postsynaptic currents (eEPSCs).

Działania biochem./fizjol.

7,8-Dihydroxyflavone (7,8-DHF) may be used to help identify and differentiate the physiological effects and cell signaling pathways mediated by TrkB activation, such as those involving, memory, vasorelaxation and hypertension. 7,8-DHF elicits protection in scopolamine induced Alzheimer-like pathologic dysfunction.

7,8-Dihydroxyflavone is a selective tyrosine kinase receptor B (TrkB) receptor agonist. It manifests all the therapeutic effects of brain-derived neurotrophic factor (BDNF)—such as protecting neurons from apoptosis, inhibiting kainic acid-induced toxicity, decreasing infarct volumes in stroke, and neuroprotecting in an animal model of Parkinson′s disease—without the poor pharmacokinetic profile of BDNF limiting its therapeutic potential.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable