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C6762

Sigma-Aldrich

Cytochalasin B from Drechslera dematioidea

≥98% (HPLC), powder

Synonim(y):

Phomin

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About This Item

Wzór empiryczny (zapis Hilla):
C29H37NO5
Numer CAS:
14930-96-2
Masa cząsteczkowa:
479.61
Beilstein:
1096207
Numer WE:
239-000-2
Numer MDL:
MFCD00077704
Kod UNSPSC:
12352202
Identyfikator substancji w PubChem:
24892890
NACRES:
NA.32

Poziom jakości

300

Próba

≥98% (HPLC)

Postać

powder

kolor

white

rozpuszczalność

DMSO: 10 mg/mL

spektrum działania antybiotyku

fungi

Tryb działania

DNA synthesis | interferes

temp. przechowywania

−20°C

ciąg SMILES

C[C@@H]1CCC[C@@H](O)\C=C\C(=O)O[C@]23[C@@H](\C=C\C1)[C@H](O)C(=C)[C@@H](C)[C@H]2[C@H](Cc4ccccc4)NC3=O

InChI

1S/C29H37NO5/c1-18-9-7-13-22(31)15-16-25(32)35-29-23(14-8-10-18)27(33)20(3)19(2)26(29)24(30-28(29)34)17-21-11-5-4-6-12-21/h4-6,8,11-12,14-16,18-19,22-24,26-27,31,33H,3,7,9-10,13,17H2,1-2H3,(H,30,34)/b14-8+,16-15+/t18-,19-,22-,23+,24+,26+,27-,29-/m1/s1

Klucz InChI

GBOGMAARMMDZGR-TYHYBEHESA-N

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Opis ogólny

Cytochalasin B is a cell-permeable fungal toxin / mycotoxin that binds to the ′barbed′ end of actin / actin filaments. This binding leads to:
  • Disruption of actin filaments and of interaction of actin filaments in solution
  • Inhibition of actin polymerization
  • Inhibition of subunit association and dissociation
Cytochalasin B is widely used in studies of glucose transporters (GLUT). Cytochalasin B is also used as an integral part of various in vitro micronucleus assay protocols.

Działania biochem./fizjol.

Cell permeable fungal toxin that disrupts contractile microfilaments by inhibiting actin polymerization. This, in turn, induces DNA fragmentation, inhibits cell division, and disrupts many cell processes. Inhibits glucose transport.
One of a group of fungal metabolites that interfere with a wide variety of cellular movements. Useful tool for characterizing some of the polymerization properties of actin, and in studies on cytokinesis. Probe for the two hexose-transport systems in rat L6 myoblasts.
This page may contain text that has been machine translated.

Piktogramy

Skull and crossbonesHealth hazard
GHS06,GHS08

Hasło ostrzegawcze

Danger

Zwroty wskazujące rodzaj zagrożenia

H300 + H310 + H330,H361

Klasyfikacja zagrożeń

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Repr. 2

Kod klasy składowania

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Klasa zagrożenia wodnego (WGK)

WGK 3

Środki ochrony indywidualnej

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Certyfikaty analizy (CoA)

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

C B Chien et al.
Neuron, 11(2), 237-251 (1993-08-01)
We have developed an exposed brain preparation for observing growth cone pathfinding behavior while performing in vivo pharmacological manipulations, and we used it to test whether Xenopus retinal growth cones need filopodia to navigate. Time-lapse video observation showed that cytochalasin
Kinga Brzozowska et al.
International journal of radiation biology, 85(10), 891-899 (2009-07-30)
It has been reported that the level of cytogenetic damage in human peripheral blood lymphocytes (PBL) is higher following irradiation at 37 degrees C than at 0-4 degrees C. The mechanisms of this cytogenetic temperature effect are not fully known.
Christian Johannes et al.
Mutation research, 701(1), 80-85 (2010-05-18)
There are conflicting data regarding the effect of culturing time of human peripheral blood lymphocytes on the yield of chromosomal aberrations induced by sparsely ionising radiation in the G0 phase of the cell cycle. While some authors find that the
Fabiana S Paula et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 47(1), 163-170 (2008-11-22)
The tamarind (Tamarindus indica L.) is indigenous to Asian countries and widely cultivated in the American continents. The tamarind fruit pulp extract (ExT), traditionally used in spices, food components and juices, is rich in polyphenols that have demonstrated anti-atherosclerotic, antioxidant
N V Ballal et al.
International endodontic journal, 52(8), 1228-1234 (2019-03-09)
To test whether the incorporation of a chelation powder, etidronate, marketed for root canal irrigation (Dual Rinse HEDP) into a sodium hypochlorite (NaOCl) solution induced additional cytotoxic and genotoxic effects not observed with NaOCl alone. Fresh and 24-h-old mixtures of
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