C1988

Cycloheximide

Biotechnology Performance Certified

• Synonim(y): 3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide, Actidione, Naramycin A
• Wzór empiryczny (zapis Hilla): C₁₅H₂₃NO₄
• Numer CAS: 66-81-9
• Masa cząsteczkowa: 281.35
• Beilstein: 88868
• Numer WE: 200-636-0
• Numer MDL: MFCD00082346
• Kod UNSPSC: 51102829
• Identyfikator substancji w PubChem: 24892457
• NACRES: NA.85

Właściwości

• klasa czystości: Biotechnology Performance Certified
• Formularz: powder
• metody: cell culture | mammalian: suitable
• zanieczyszczenia: endotoxin, tested
• rozpuszczalność: ethanol: 50 mg/mL
• spektrum działania antybiotyku: fungi; yeast
• Tryb działania: protein synthesis | interferes
• temp. przechowywania: 2-8°C
• ciąg SMILES: [H][C@]1(C[C@@H](C)C[C@H](C)C1=O)[C@H](O)CC2CC(=O)NC(=O)C2
• InChI: 1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1
• Klucz InChI: YPHMISFOHDHNIV-FSZOTQKASA-N
• informacje o genach: human ... FKBP1A(2280) , PIN1(5300)

Opis

Zastosowanie

Cycloheximide is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors. It has been shown to selectively clear macrophages in atherosclerotic plaques and activate cumulus-free equine oocytes.

Działania biochem./fizjol.

Cycloheximide (CHX) is an antibiotic produced by S. griseus that inhibits protein biosynthesis in eukaryotes. It inactivate transferase II enzyme that is involved in peptide chain elongation. More recent studies revealed that CHX binds the 60S ribosome and specifically prevents the translocation step in elongation.

Mode of Action: Translation inhibition in eukaryotes resulting in cell growth arrest and cell death. CHX is widely used for the selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors.

Activity Spectrum: Active against yeast and fungi like Candida, Aspergillus, Saccharomyces, Penicillium

Inne uwagi

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS06,GHS08,GHS09
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H300,H341,H360D,H411
• Zwroty wskazujące środki ostrożności: P201 - P202 - P264 - P270 - P273 - P301 + P310
• Klasyfikacja zagrożeń: Acute Tox. 2 Oral - Aquatic Chronic 2 - Muta. 2 - Repr. 1B
• Kod klasy składowania: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges