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Key Documents

239765

Sigma-Aldrich

Cycloheximide

InSolution, 100 mg/mL in DMSO, Suitable for cell culture

Synonim(y):

InSolution Cycloheximide

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About This Item

Wzór empiryczny (zapis Hilla):
C15H23NO4
Numer CAS:
Masa cząsteczkowa:
281.35
Numer MDL:
Kod UNSPSC:
12352111
NACRES:
NA.77

Poziom jakości

Postać

solution

producent / nazwa handlowa

Calbiochem®

stężenie

100 mg/mL in DMSO

rozpuszczalność

DMSO: soluble

temp. przechowywania

2-8°C

InChI

1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1

Klucz InChI

YPHMISFOHDHNIV-FSZOTQKASA-N

Opis ogólny

A convenient ready-to-use form of Cycloheximide (Cat. No. 239763). An anti-fungal antibiotic that inhibits protein synthesis in eukaryotes but not in prokaryotes. Interacts directly with the translocase enzyme, interfering with the translocation step. Also inhibits cell-free protein synthesis in eukaryotes. Competitively inhibits hFKBP12 (Ki = 3.4 µM). Triggers apoptosis in HL-60 cells, T-cell hybridomas, Burkitt′s lymphoma cells, and a variety of other cell types, including rodent macrophages. Induces DNA fragmentation in macrophages, but inhibits DNA cleavage in rat thymocytes treated with thapsigargin, methylprednisolone, and ionomycin. Rapidly destroyed in alkaline solutions.

Działania biochem./fizjol.

Primary Target
hFKBP12

Opakowanie

Packaged under inert gas

Ostrzeżenie

Toxicity: Highly Toxic & Carcinogenic / Teratogenic (I)

Postać fizyczna

A 100 mg/ml solution of Cycloheximide (Cat. No. 239763) in DMSO (sterile-filtered).

Rekonstytucja

Following initial use, aliquot and refrigerate (4°C).

Inne uwagi

Christner, C., et al. 1999. J. Med. Chem.42, 3615.
Lu, Q. and Mellgreen,R.L. 1996. Arch. Biochem. Biophys.334, 175.
Chow, S.C., et al. 1995. Exp. Cell Res.216, 149.
Waring, P. 1990. J. Biol. Chem.265, 14476.
Obrig, T.G., et al. 1971. J. Biol. Chem.246, 174.
Pestka, S. 1971. Annu. Rev. Microbiol.25, 487.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Informacje prawne

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
This page may contain text that has been machine translated.

Piktogramy

Skull and crossbonesHealth hazard

Hasło ostrzegawcze

Danger

Zwroty wskazujące rodzaj zagrożenia

Zwroty wskazujące środki ostrożności

Klasyfikacja zagrożeń

Acute Tox. 3 Oral - Aquatic Chronic 3 - Muta. 2 - Repr. 1B

Kod klasy składowania

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Klasa zagrożenia wodnego (WGK)

WGK 3


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