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A9511

Sigma-Aldrich

Albumin from human serum

lyophilized powder, ≥97% (agarose gel electrophoresis)

Synonim(y):

HSA

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About This Item

Numer CAS:
70024-90-7
Numer WE:
274-272-6
Numer MDL:
MFCD00081418
Kod UNSPSC:
12352202
eCl@ss:
42010201
NACRES:
NA.25

pochodzenie biologiczne

human

Poziom jakości

300

Próba

≥97% (agarose gel electrophoresis)

Postać

lyophilized powder

masa cząsteczkowa

monomer calculated mol wt 66478 Da

metody

ELISA: suitable
tissue culture: suitable
western blot: suitable

zanieczyszczenia

HIV I and HIVII, HCV and HBsAg, tested negative

rozpuszczalność

H2O: soluble 50 mg/mL

numer dostępu UniProt

P02768

temp. przechowywania

2-8°C

InChI

1S/C3F8/c4-1(5,2(6,7)8)3(9,10)11

Klucz InChI

QYSGYZVSCZSLHT-UHFFFAOYSA-N

informacje o genach

human ... ALB(213)

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Opis ogólny

Albumin is the most copious protein in blood plasma. Liver produces human albumin.
Human albumin possess a molecular weight of 67 kDa.

Zastosowanie

Albumin from human serum has been used:
  • to standardize the column for molecular-exclusion chromatography
  • to prepare the tobacco mosaic virus (TMV)-poly ethylene glycol (PEG8)-serum albumin (SA) particles
  • to analyze its modifications after oxidation using a Fenton system

Albumin-bound fluorescence was used in serum of patients with chronic renal failure.

Działania biochem./fizjol.

Albumin turnover is seen in infants with iron deficiency anemia. Serum albumin is a reliable prognostic indicator in liver disease. Oxidative modification of albumin is seen in advanced liver disease.
Serum albumin functions as a carrier protein for steroids, fatty acids, and thyroid hormones, and is vital in regulating the colloidal osmotic pressures of blood. Albumin is also seen to bind to exogenous substances, particularly drugs (e.g., ibuprofen, warfarin), and strongly influence their pharmacokinetics. Oxidative stress leading to changes in the redox state of albumin has widely varied effects on its physiological function.

Uwaga dotycząca przygotowania

Prepared using method IV of Cohn, E.J., et al., J. Am. Chem. Soc., 69, 1753 (1947).

Inne uwagi

View more information on human serum albumin.

Oświadczenie o zrzeczeniu się odpowiedzialności

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
This page may contain text that has been machine translated.

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

Eyeshields, Gloves

Certyfikaty analizy (CoA)

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Odwiedź Bibliotekę dokumentów

Effects of Fenton Reaction on Human Serum Albumin: An In Vitro Study
Khosravifarsani M, et al.
Electron Physician, 8(9), 2970-2970 (2016)
Elham Behzadi et al.
International journal of nanomedicine, 14, 257-270 (2019-01-16)
Recently, nanomaterials have moved into biological and medicinal implementations like cancer therapy. Therefore, before clinical trials, their binding to plasma proteins like human serum albumin (HSA) and their cytotoxic effects against normal and cancer cell lines should be addressed. Herein
Daniele Sanna et al.
Inorganic chemistry, 48(13), 5747-5757 (2009-06-12)
The complexation of the VO(2+) ion in several systems that can model the physiological conditions of its transport in blood serum was studied using electron paramagnetic resonance (EPR) spectroscopy. Particularly, the ternary systems formed by (i) VO(2+) and two high-molecular-mass
Fibrillation and Polymorphism of Human Serum Albumin
Bio-nanoimaging, 345-362 (2014)
Serum albumin camouflage of plant virus based nanoparticles prevents their antibody recognition and enhances pharmacokinetics
Pitek A, et al.
Biomaterials, 89(7-8), 89-97 (2016)
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Produkty

Albumin in Cell Culture

This page segues to comprehensive insights on how serum albumin and other important cell culture components affect the performance of serum-free cell culture systems used for biomanufacturing heterologous proteins including monoclonal antibodies. The page introduces the in vitro chemistry and biochemistry of albumin. These insights may also be applied to ex vivo and tissue engineering applications.

Nasz zespół naukowców ma doświadczenie we wszystkich obszarach badań, w tym w naukach przyrodniczych, materiałoznawstwie, syntezie chemicznej, chromatografii, analityce i wielu innych dziedzinach.

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