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Merck

PHR1425

Supelco

Benzethonium Chloride

Pharmaceutical Secondary Standard; Certified Reference Material

Synonim(y):

Benzethonium chloride, (Diisobutylphenoxyethoxyethyl)dimethylbenzylammonium chloride, Phemerol chloride

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About This Item

Wzór empiryczny (zapis Hilla):
C27H42ClNO2
Numer CAS:
Masa cząsteczkowa:
448.08
Beilstein:
3898548
Numer WE:
Numer MDL:
Kod UNSPSC:
41116107
Identyfikator substancji w PubChem:
NACRES:
NA.24

klasa czystości

certified reference material
pharmaceutical secondary standard

Poziom jakości

agency

traceable to Ph. Eur. B0550000
traceable to USP 1051500

rodzina API

benzethonium chloride

Certyfikat analizy

current certificate can be downloaded

metody

HPLC: suitable
gas chromatography (GC): suitable

mp

162-164 °C (lit.)

Zastosowanie

pharmaceutical (small molecule)

Format

neat

temp. przechowywania

2-30°C

ciąg SMILES

[Cl-].CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1

InChI

1S/C27H42NO2.ClH/c1-26(2,3)22-27(4,5)24-13-15-25(16-14-24)30-20-19-29-18-17-28(6,7)21-23-11-9-8-10-12-23;/h8-16H,17-22H2,1-7H3;1H/q+1;/p-1

Klucz InChI

UREZNYTWGJKWBI-UHFFFAOYSA-M

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Opis ogólny

Benzethonium Chloride, a quaternary ammonium drug, exhibits anti-infective, antiseptic and anticancer activities. It is commonly used in various commercial applications including eye and nasal drops, soaps, mouthwash, and cosmetics.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Zastosowanie

Benzethonium Chloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Komentarz do analizy

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Inne uwagi

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Przypis

To see an example of a Certificate of Analysis for this material enter LRAA2733 in the slot below. This is an example certificate only and may not be the lot that you receive.

Polecane produkty

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
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Hasło ostrzegawcze

Danger

Zwroty wskazujące rodzaj zagrożenia

Klasyfikacja zagrożeń

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Corr. 1B

Kod klasy składowania

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Klasa zagrożenia wodnego (WGK)

WGK 2


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Certyfikaty analizy (CoA)

Lot/Batch Number

Przepraszamy, ale COA dla tego produktu nie jest aktualnie dostępny online.

Proszę o kontakt, jeśli potrzebna jest pomoc Obsługa Klienta

Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Determination of benzalkonium chloride preservative in pharmaceutical formulation of eye and ear drops using new potentiometric sensors
Gaber M, et al.
Materials Science and Engineering, C, 32(8), 2299-2305 (2012)
Development and validation of a capillary zone electrophoresis method for the determination of benzalkonium chlorides in ophthalmic solutions
Hou YH, et al.
Journal of Chromatography A, 976(1-2), 207-213 (2002)
Effects of consumer antimicrobials benzalkonium chloride, benzethonium chloride, and chloroxylenol on colonic inflammation and colitis-associated colon tumorigenesis in mice
Sanidad KZ, et al.
Toxicological Sciences, 163(2), 490-499 (2018)
Studies on the interactions of some small biomolecules with antibacterial drug benzethonium chloride and its active pharmaceutical ingredient ionic liquid (API-IL) benzethonium L-proline at varying temperatures
Yan Z, et al.
Journal of Molecular Liquids, 255, 530-540 (2018)
T Marques et al.
Clinica chimica acta; international journal of clinical chemistry, 444, 170-175 (2015-02-24)
Mesangial cells subject to high extracellular glucose concentrations, as occur in hyperglycaemic states, are unable to down regulate glucose influx, resulting in intracellular activation of deleterious biochemical pathways. A high expression of GLUT1 participates in the development of diabetic glomerulopathy.

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