45674

Erythromycin

tested according to Ph. Eur.

• Synonim(y): Erythromycinum
• Wzór empiryczny (zapis Hilla): C₃₇H₆₇NO₁₃
• Numer CAS: 114-07-8
• Masa cząsteczkowa: 733.93
• Beilstein: 75279
• Numer WE: 204-040-1
• Numer MDL: MFCD00084654
• Kod UNSPSC: 51282304
• Identyfikator substancji w PubChem: 329756889
• NACRES: NA.76

Właściwości

• agency: EPA 1694; USP/NF; tested according to Ph. Eur.
• Poziom jakości: 200
• Postać: solid
• kolor: white to faint yellow
• rozpuszczalność: H₂O: soluble 2 mg/mL; acetone: freely soluble; acetonitrile: freely soluble; alcohol: soluble; amyl acetate: moderately soluble; chloroform: soluble; diethyl ether: soluble; ethyl acetate: freely soluble
• spektrum działania antybiotyku: Gram-negative bacteria; Gram-positive bacteria
• Zastosowanie: environmental
• Tryb działania: protein synthesis | interferes
• ciąg SMILES: CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O
• InChI: 1S/C37H67NO13/c1-14-25-37(10,45)30(41)20(4)27(39)18(2)16-35(8,44)32(51-34-28(40)24(38(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-36(9,46-13)31(42)23(7)48-26/h18-26,28-32,34,40-42,44-45H,14-17H2,1-13H3/t18-,19-,20+,21+,22-,23+,24+,25-,26+,28-,29+,30-,31+,32-,34+,35-,36-,37-/m1/s1
• Klucz InChI: ULGZDMOVFRHVEP-RWJQBGPGSA-N
• informacje o genach: human ... ABCB1(5243) , CYP3A4(1576) , MLNR(2862) ; mouse ... Abcb1a(18671) , Abcb1b(18669)

Opis

Opis ogólny

Chemical structure: macrolide

Zastosowanie

Erythromycin is an antibiotic produced by growth of certain strains of Streptomyces erythreus. This product is composed largely of erythromycin A with small amounts of erythromycins B and C and is recommended for concentration at 100 mg/L. Concentrations between 50 and 200 mg/L have also proven effective in controlling bacterial growth. Erythromycin has been used as a motilin receptor agonist, to block respiratory glycoconjugate secretion in human airways in vitro††, and for selecting plasmid-cured and recombinant lactococcus lactis MG1363 strains.

Działania biochem./fizjol.

Mode of Action: Erythromycin acts by inhibiting elongation at the transpeptidation step, specifically aminoacyl translocation from the A-site to P-site by binding to the 50s subunit of the bacterial 70s rRNA complex.

Antimicrobial Spectrum: This product acts against both gram-negative and gram-positive bacteria.

Opakowanie

25g

Przestroga

This product is stable in solution at 37°C for 3 days. Stock solutions should be stored at 2-8°C.

Uwaga dotycząca przygotowania

This product is soluble in water at 2 mg/mL, with a 0.067% solution in water yielding a pH of 8.0-10.5. It is also soluble in ethanol at 50 mg/mL, yielding a clear, colorless to faint yellow solution. It is freely soluble in alcohol, acetone, chloroform, acetonitrile and ethyl acetate but forms salts with acids. All solutions should be protected from light.

Inne uwagi

Keep container tightly closed in a dry and well-ventilated place.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, type N95 (US)