E0774

Erythromycin

meets USP testing specifications

• Synonim(y): Erythromycin A
• Wzór empiryczny (zapis Hilla): C₃₇H₆₇NO₁₃
• Numer CAS: 114-07-8
• Masa cząsteczkowa: 733.93
• Beilstein: 75279
• Numer WE: 204-040-1
• Numer MDL: MFCD00084654
• Kod UNSPSC: 51282304
• Identyfikator substancji w PubChem: 24894374
• NACRES: NA.76

Właściwości

• agency: USP/NF; meets USP testing specifications
• Poziom jakości: 200
• Postać: solid
• aktywność optyczna: [α]/D -78 to --71°
• rozpuszczalność: ethanol: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow
• spektrum działania antybiotyku: Gram-negative bacteria; Gram-positive bacteria
• Zastosowanie: pharmaceutical (small molecule)
• Tryb działania: protein synthesis | interferes
• ciąg SMILES: CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O
• InChI: 1S/C37H67NO13/c1-14-25-37(10,45)30(41)20(4)27(39)18(2)16-35(8,44)32(51-34-28(40)24(38(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-36(9,46-13)31(42)23(7)48-26/h18-26,28-32,34,40-42,44-45H,14-17H2,1-13H3/t18-,19-,20+,21+,22-,23+,24+,25-,26+,28-,29+,30-,31+,32-,34+,35-,36-,37-/m1/s1
• Klucz InChI: ULGZDMOVFRHVEP-RWJQBGPGSA-N
• informacje o genach: human ... ABCB1(5243) , CYP3A4(1576) , MLNR(2862) ; mouse ... Abcb1a(18671) , Abcb1b(18669)

Opis

Opis ogólny

Chemical structure: macrolide

Zastosowanie

Erythromycin is an antibiotic produced by growth of certain strains of Streptomyces erythreus. This product is composed largely of erythromycin A with small amounts of erythromycins B and C and is recommended for concentration at 100 mg/L. Concentrations between 50 and 200 mg/L have also proven effective in controlling bacterial growth. Erythromycin has been used as a motilin receptor agonist, to block respiratory glycoconjugate secretion in human airways in vitro, and for selecting plasmid-cured and recombinant lactococcus lactis MG1363 strains.

Działania biochem./fizjol.

Mode of Action: Erythromycin acts by inhibiting elongation at the transpeptidation step, specifically aminoacyl translocation from the A-site to P-site by binding to the 50s subunit of the bacterial 70s rRNA complex.

Antimicrobial Spectrum: This product acts against both gram-negative and gram-positive bacteria.

Przestroga

This product is stable in solution at 37°C for 3 days. Stock solutions should be stored at 2-8°C.

Uwaga dotycząca przygotowania

This product is soluble in water at 2 mg/mL, with a 0.067% solution in water yielding a pH of 8.0-10.5. It is also soluble in ethanol at 50 mg/mL, yielding a clear, colorless to faint yellow solution. It is freely soluble in alcohol, acetone, chloroform, acetonitrile and ethyl acetate but forms salts with acids. All solutions should be protected from light.

This page may contain text that has been machine translated.

Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable