ABN1362
Anti-RBPMS Antibody
from rabbit, purified by affinity chromatography
Synonim(y):
RNA-binding protein with multiple splicing, RBPMS, RBP-MS, Heart and RRM expressed sequence, Hermes
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About This Item
Kod UNSPSC:
12352203
eCl@ss:
32160702
Polecane produkty
pochodzenie biologiczne
rabbit
Poziom jakości
forma przeciwciała
affinity isolated antibody
rodzaj przeciwciała
primary antibodies
klon
polyclonal
oczyszczone przez
affinity chromatography
reaktywność gatunkowa
human, mouse, rat
metody
immunofluorescence: suitable
western blot: suitable
numer dostępu NCBI
numer dostępu UniProt
Warunki transportu
wet ice
docelowa modyfikacja potranslacyjna
unmodified
informacje o genach
human ... RBPMS(11030)
Opis ogólny
RNA-binding protein with multiple splicing (UniProt Q93062; also known as Heart and RRM expressed sequence, Hermes, RBP-MS) is encoded by the RBPMS (also known as HERMES) gene (Gene ID 11030) in human. RBPMS is a member of the RRM (RNA recognition motif) family of RNA-binding proteins. Transcriptome-wide study using photoactivatable-ribonucleoside-enhanced crosslinking and immunoprecipitation (PAR-CLIP) in HEK293 cells reveals both exonic mature and intronic pre-mRNA-binding sites, in agreement with the nuclear and cytoplasmic localization of the RRM family proteins. RBPMS is found to be exclusively expressed in retinal ganglion cells (RGCs) and displaced RGCs (dRGCs). RBPMS expression can therefore be utitized as a RGC marker, and the RBPMS gene promoter could be utilized for driving RGC-specific transgene expression.
Specyficzność
Expected to react with all five spliced isoforms (UniProt Q93062-1 through Q93062-5).
Immunogen
Epitope: N-terminal region.
KLH-conjugated linear peptide corresponding to a sequence from the N-terminal region of human RBPMS.
Zastosowanie
Anti-RBPMS Antibody is an antibody against RBPMS for use in Western Blotting, Immunofluorescence.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Sensory & PNS
Sensory & PNS
Western Blotting Analysis: A representative lot detected endogenous RBPMS in mouse and rat retina extracts, as well as exogenously expressed human RBPMS in transfected HEK293T cells (Rodriguez, A.R., et al. (2014). J. Comp. Neurol. 522(6):1411-1443).
Immunofluorescence Analysis: A representative lot detected RBPMS immunoreactivity primarily associated with cell bodies located in the ganglion cell layer (GCL) of paraformaldehyde-fixed mouse retinas by fluorescent immunohistochemistry using whole-mounted retinas (Rodriguez, A.R., et al. (2014). J. Comp. Neurol. 522(6):1411-1443).
Immunofluorescence Analysis: An 1:5,000 dilution of a representative lot detected RBPMS immunoreactivity among cells in the ganglion cell layer (GCL) of paraformaldehyde-fixed mouse retinas by fluorescent immunohistochemistry (Courtesy of Dr. Nicholas Brecha, David Geffen School of Medicine at UCLA).
Immunofluorescence Analysis: A representative lot detected RBPMS immunoreactivity primarily associated with cell bodies located in the ganglion cell layer (GCL) of paraformaldehyde-fixed mouse retinas by fluorescent immunohistochemistry using whole-mounted retinas (Rodriguez, A.R., et al. (2014). J. Comp. Neurol. 522(6):1411-1443).
Immunofluorescence Analysis: An 1:5,000 dilution of a representative lot detected RBPMS immunoreactivity among cells in the ganglion cell layer (GCL) of paraformaldehyde-fixed mouse retinas by fluorescent immunohistochemistry (Courtesy of Dr. Nicholas Brecha, David Geffen School of Medicine at UCLA).
Jakość
Evaluated by Western Blotting in mouse embryonic stem cell (mESC) lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected RBPMS in 10 µg of mouse embryonic stem cell (mESC) lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected RBPMS in 10 µg of mouse embryonic stem cell (mESC) lysate.
Opis wartości docelowych
~25 kDa observed
Postać fizyczna
Affinity purified
Purified rabbit polyclonal antibody in PBS with 1% BSA and 0.09 % sodium azide.
Przechowywanie i stabilność
Stable for 1 year at 2-8°C from date of receipt.
Inne uwagi
Concentration: Please refer to lot specific datasheet.
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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polecane
Kod klasy składowania
12 - Non Combustible Liquids
Klasa zagrożenia wodnego (WGK)
WGK 2
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Certyfikaty analizy (CoA)
Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.
Masz już ten produkt?
Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Alexandra Bernardo-Colón et al.
Frontiers in neuroscience, 13, 719-719 (2019-07-30)
Indirect traumatic optic neuropathy (ITON) is a condition that is often associated with traumatic brain injury and can result in significant vision loss due to degeneration of retinal ganglion cell (RGC) axons at the time of injury or within the
Chelsea Guymer et al.
Translational vision science & technology, 9(6), 28-28 (2020-08-22)
The ability to accurately quantify immunohistochemically labeled retinal ganglion cells (RGCs) on wholemounts is an important histopathological determinant in experimental retinal research. Traditionally, this has been performed by manual or semi-automated counting of RGCs. Here, we describe an automated software
Jing Luo et al.
Molecular therapy. Methods & clinical development, 20, 551-558 (2021-03-06)
The anti-inflammatory molecule annexin A1 (ANXA1) determines the ultimate fate of retinal ganglion cell (RGC) in glaucoma. Cytoplasmic and extracellular ANXA1 facilitate resolution of inflammation. However, the nuclear translocation of ANXA1 induces RGC apoptosis in a murine glaucoma model, and
Lucia G Le Roux et al.
Cells, 9(5) (2020-05-28)
We illuminate a possible explanatory pathophysiologic mechanism for retinal cellular neuropathy by means of a novel diagnostic method using ophthalmoscopic imaging and a molecular imaging agent targeted to fast axonal transport. The retinal neuropathies are a group of diseases with
Qi Lu et al.
Molecular therapy. Methods & clinical development, 18, 15-23 (2020-06-18)
The loss of photoreceptors in individuals with retinal degenerative diseases leads to partial or complete blindness. Optogenetic therapy is a promising approach for restoring vision to the blind. Multiple strategies have been employed by targeting genetically encoded light sensors, particularly
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