8.00907

N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride

for peptide synthesis

• Synonim(y): N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride
• Wzór empiryczny (zapis Hilla): C₈H₁₇N₃ · xHCl
• Numer CAS: 25952-53-8
• Masa cząsteczkowa: 155.24 (free base basis)
• Numer MDL: MFCD00012503
• Kod UNSPSC: 12352107
• Numer indeksu EC: 247-361-2
• NACRES: NA.22

Właściwości

• product name: N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride, for synthesis
• Poziom jakości: 200
• Postać: solid
• przydatność reakcji: reaction type: Coupling Reactions
• mp: 110-115 °C
• Zastosowanie: peptide synthesis
• temp. przechowywania: −20°C (−15°C to −25°C)
• InChI: 1S/C8H17N3.ClH/c1-4-11(8-9)7-5-6-10(2)3;/h4-7H2,1-3H3;1H
• Klucz InChI: FDXPUDRRFDHONO-UHFFFAOYSA-N

Opis

Opis ogólny

N-(3-Dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride, also known as EDAC HCl or WSC, is a water-soluble condensing reagent. EDAC HCl is generally used to couple carboxylic acids with amines to form amides. The by-product urea is water-soluble and can be removed from immiscible reaction milieux by extraction with water. It is principally utilized in solution-phase peptide synthesis and as a zero-length crosslinker for protein modification.

Zastosowanie

N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (EDC hydrochloride) can be used as:

• A water-soluble carbodiimide to facilitate peptide coupling reactions in alcohols.
• A coupling agent along with HOBt to synthesize poly(glutamic acid) (PGA) polypeptides for the creation of non-fouling polypeptides that could be useful in a variety of biomedical applications.
• A coupling reagent for the efficient synthesis of teriflunomide at the industrial scale.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS06,GHS08,GHS09
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H302 - H311 - H315 - H317 - H373 - H410
• Zwroty wskazujące środki ostrożności: P260 - P273 - P280 - P301 + P312 - P302 + P352 + P312 - P314
• Klasyfikacja zagrożeń: Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2 Oral
• Kod klasy składowania: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable