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Merck
Wszystkie zdjęcia(1)

Kluczowe dokumenty

14-155

Sigma-Aldrich

Białko histonu H1, 20 mg

Purified bovine Histone H1 protein for use as a substrate in histone modification assays (HAT, HDAC, DNMT) and chromatin assembly studies.

Synonim(y):

Łącznik Histone H1

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About This Item

Kod UNSPSC:
12352202
eCl@ss:
32160405
NACRES:
NA.32

pochodzenie biologiczne

bovine

Poziom jakości

masa cząsteczkowa

Mw 32 kDa

producent / nazwa handlowa

Upstate®

metody

activity assay: suitable (kinase)

numer dostępu NCBI

numer dostępu UniProt

Warunki transportu

dry ice

Opis ogólny

H1 and related linker histones are important both for maintenance of higher-order chromatin structure and for the regulation of gene expression. Nucleosomal stabilization is provided through the binding of histone H1 to the nucleosomal dyad and the linker DNA entering and exiting the core particle. Additional experimental evidence illustrates the influence of histone H1 on chromatin arrangement and compaction. The family of histone H1 proteins contains five somatic variants (H1.1, H1.2, H1.3, H1.4 and H1.5) which are expressed in nearly all cell types.
Product Source: Lysine rich fraction from calf thymus

Jakość

Routinely evaluated by Kinase assay using cdk2/cyclin A, active (14-448) to phosphorylate Histone H1.

Postać fizyczna

Sterilized through a 0.2 micron membrane filter

Przechowywanie i stabilność

1 year at -20°C

Inne uwagi

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
This product is derived from bovine source. Export of this product to certain countries may be restricted. Please contact Customer Service or your local distributor to inquire about product availability and export options.

Informacje prawne

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania

12 - Non Combustible Liquids

Klasa zagrożenia wodnego (WGK)

nwg

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable


Certyfikaty analizy (CoA)

Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Sabrina Absalon et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(37), 14645-14659 (2013-09-13)
MicroRNA (miRNA) functions in the pathogenesis of major neurodegenerative diseases such as Alzheimer's disease (AD) are only beginning to emerge. We have observed significantly elevated levels of a specific miRNA, miR-26b, in the defined pathological areas of human postmortem brains
Hyo Kyun Chung et al.
The Journal of biological chemistry, 278(30), 28079-28088 (2003-04-30)
The Gadd45 family of proteins includes Gadd45alpha, MyD118/Gadd45beta, and CR6/OIG37/Gadd45gamma. These proteins play important roles in maintaining genomic stability and in regulating the cell cycle. This study reports the cloning of a novel protein called CR6-interacting factor 1 (CRIF1) which
Pim3 negatively regulates glucose-stimulated insulin secretion.
Gregory Vlacich,Martijn C Nawijn,Gene C Webb,Donald F Steiner
Islets null
B Ouyang et al.
The Journal of biological chemistry, 272(45), 28646-28651 (1997-11-14)
Human prk encodes a novel protein serine/threonine kinase capable of strongly phosphorylating casein but not histone H1 in vitro. prk expression is tightly regulated at various levels during different stages of the cell cycle in lung fibroblasts. The Prk kinase
Mihkel Örd et al.
Cell reports, 31(11), 107757-107757 (2020-06-20)
The hydrophobic patch (hp), a docking pocket on cyclins of CDKs (cyclin-dependent kinases), has been thought to accommodate a single short linear motif (SLiM), the "RxL or Cy" docking motif. Here we show that hp can bind different motifs with

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