1.06757

Methyl 4-hydroxybenzoate

EMPROVE^® ESSENTIAL, Ph. Eur., BP, JP, NF

• Synonim(y): Methyl 4-hydroxybenzoate, Methylparaben, 4-Hydroxybenzoic acid methyl ester
• Wzór liniowy: 4-(OH)C₆H₄(COOCH₃)
• Numer CAS: 99-76-3
• Masa cząsteczkowa: 152.15
• Numer MDL: MFCD00002352
• Kod UNSPSC: 12352108
• Numer indeksu EC: 202-785-7

Właściwości

• agency: BP; JP; NF; Ph. Eur.
• Poziom jakości: 500
• ciśnienie pary: 0.000005 hPa ( 20 °C)
• linia produktu: EMPROVE^® ESSENTIAL
• Próba: 99.0-100.5% (HPLC); 99.0-102.0% (acidimetric)
• Postać: solid
• temp. samozapłonu: >600 °C
• metody: API processing | cocrystal formation: suitable
• pH: 5.8 (20 °C in H₂O, saturated solution)
• mp: 125 °C
• rozpuszczalność: 1.88 g/L
• gęstość: 1.38 g/cm³ at 20 °C
• Zastosowanie: liquid formulation; ophthalmics; pharmaceutical; semi-solid formulation; solid formulation
• temp. przechowywania: 15-25°C
• InChI: 1S/C8H8O3/c1-11-8(10)6-2-4-7(9)5-3-6/h2-5,9H,1H3
• Klucz InChI: LXCFILQKKLGQFO-UHFFFAOYSA-N

Opis

Opis ogólny

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Zastosowanie

Methyl 4-hydroxybenzoate has antimicrobial characteristics and is used as preservative in pharmaceutical formulations and cosmetics. It can be combined with other parabens like propyl 4-hydroxybenzoate or ethyl 4-hydroxybenzoate.

Informacje prawne

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Oświadczenie o zrzeczeniu się odpowiedzialności

The product is not intended for use as a biocide under global biocide regulations, including but not limited to US EPA′s Federal Insecticide Fungicide and Rodenticide Act, European Biocidal Products Regulation, Canada’s Pest Management Regulatory Agency, Turkey’s Biocidal Products Regulation, Korea’s Consumer Chemical Products and Biocide Safety Management Act (K-BPR) and others.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS09
• Zwroty wskazujące rodzaj zagrożenia: H411
• Zwroty wskazujące środki ostrożności: P273 - P391 - P501
• Klasyfikacja zagrożeń: Aquatic Chronic 2
• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): 334.4 °F
• Temperatura zapłonu (°C): 168 °C