Wszystkie zdjęcia(1)
Key Documents
T-911
α-Hydroxytriazolam solution
1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
Zaloguj sięWyświetlanie cen organizacyjnych i kontraktowych
About This Item
Wzór empiryczny (zapis Hilla):
C17H12Cl2N4O
Numer CAS:
Masa cząsteczkowa:
359.21
Numer WE:
Kod UNSPSC:
41116107
NACRES:
NA.24
Polecane produkty
klasa czystości
certified reference material
Postać
liquid
Właściwości
Snap-N-Spike®/Snap-N-Shoot®
opakowanie
ampule of 1 mL
producent / nazwa handlowa
Cerilliant®
stężenie
1.0 mg/mL in methanol
metody
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
Zastosowanie
clinical testing
format
single component solution
temp. przechowywania
2-8°C
ciąg SMILES
OCc1nnc2CN=C(c3ccccc3Cl)c4cc(Cl)ccc4-n12
InChI
1S/C17H12Cl2N4O/c18-10-5-6-14-12(7-10)17(11-3-1-2-4-13(11)19)20-8-15-21-22-16(9-24)23(14)15/h1-7,24H,8-9H2
Klucz InChI
BHUYWUDMVCLHND-UHFFFAOYSA-N
Szukasz podobnych produktów? Odwiedź Przewodnik dotyczący porównywania produktów
Opis ogólny
a-Hydroxytriazolam is a major urinary and blood metabolite of the benzodiazepine, triazolam, a pharmaceutical used to treat severe insomnia. This certified solution standard is suitable for use in LC/MS or GC/MS applications for clinical toxicology, forensic analysis, urine drug testing, or pharmaceutical research.
Zastosowanie
- Pharmacokinetic analysis of benzodiazepines: alpha-Hydroxytriazolam solution is employed in the quantitation of benzodiazepines and their metabolites in biological fluids using liquid chromatography-tandem mass spectrometry, providing accurate pharmacokinetic profiles that are essential for clinical and forensic analysis (Zheng et al., 2018).
- Receptor binding studies: The application of high-purity alpha-Hydroxytriazolam in receptor binding studies enables researchers to elucidate the interaction mechanisms of benzodiazepine analogs at the molecular level, thereby enhancing the understanding of their pharmacological effects (Minegishi et al., 2021).
- Development of analytical methods: alpha-Hydroxytriazolam solution serves as a critical analytical standard in the development of robust assays for the detection and quantification of benzodiazepines in various matrices, facilitating advancements in toxicological and pharmacological research (Lahr et al., 2020).
- Forensic and clinical toxicology: Utilized in forensic science, alpha-Hydroxytriazolam solution aids in the rapid determination of benzodiazepines and their metabolites in urine samples, crucial for the accurate interpretation of toxicological data (Jeong et al., 2015).
- Scientific research in biochemistry: alpha-Hydroxytriazolam research compounds are vital for studying the metabolic pathways and degradation profiles of triazolam and related benzodiazepines, supporting biochemists in drug metabolism and pharmacokinetics research (Jin et al., 2011).
Informacje prawne
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
This page may contain text that has been machine translated.
produkt powiązany
Hasło ostrzegawcze
Danger
Zwroty wskazujące rodzaj zagrożenia
Zwroty wskazujące środki ostrożności
Klasyfikacja zagrożeń
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
Organy docelowe
Eyes,Central nervous system
Kod klasy składowania
3 - Flammable liquids
Klasa zagrożenia wodnego (WGK)
WGK 2
Temperatura zapłonu (°F)
49.5 °F - closed cup
Temperatura zapłonu (°C)
9.7 °C - closed cup
Certyfikaty analizy (CoA)
Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.
Masz już ten produkt?
Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Qiran Sun et al.
Journal of analytical toxicology, 34(2), 89-94 (2010-03-13)
A sensitive liquid chromatography-tandem mass spectrometry method is presented for determination of triazolam and alpha-hydroxytriazolam in guinea pig hair after a single dose of triazolam. Eighteen guinea pigs were divided into three dosage groups (10, 100, and 500 microg/kg) and
F S Eberts et al.
Clinical pharmacology and therapeutics, 29(1), 81-93 (1981-01-01)
Triazolam (T) is a new, potent hypnotic with a short duration of action in man. After an 0.88-mg oral dose of T-14C in six male subjects, mean recovery of 14C radioactivity was 85% in urine and 8% in feces. The
Dong-Liang Lin et al.
Journal of analytical toxicology, 29(2), 118-123 (2005-05-21)
As an approved medicinal product and reportedly an abused substance that have been associated with death and "considered to be a factor...of impaired driving, sexual assault, and other violent crimes", triazolam is controlled at the same level (Level III) as
A D Fraser et al.
Journal of analytical toxicology, 16(6), 347-350 (1992-11-01)
Triazolam is a very short-acting triazolobenzodiazepine with sedative-hypnotic properties. Approximately 2% of an oral dose is excreted unchanged in the urine. The major urinary metabolite is alpha-hydroxytriazolam glucuronide (70% of the dose). The objective of this study was to characterize
Dora Farkas et al.
Journal of clinical pharmacology, 47(3), 286-294 (2007-02-27)
The effect of pomegranate juice (PJ) or grapefruit juice (GFJ) on CYP3A activity was studied in vitro and in healthy human volunteers. In human liver microsomes, the mean 50% inhibitory concentrations (IC(50)) for PJ and GFJ versus CYP3A (triazolam alpha-hydroxylation)
Nasz zespół naukowców ma doświadczenie we wszystkich obszarach badań, w tym w naukach przyrodniczych, materiałoznawstwie, syntezie chemicznej, chromatografii, analityce i wielu innych dziedzinach.
Skontaktuj się z zespołem ds. pomocy technicznej