700113P

7α-hydroxycholestenone

Avanti Research^™ - A Croda Brand

• Synonim(y): C4; α-HC; α-HC; 7HCO; 7 α-3ox-C; 111107
• Wzór empiryczny (zapis Hilla): C₂₇H₄₄O₂
• Numer CAS: 3862-25-7
• Masa cząsteczkowa: 400.64
• Kod UNSPSC: 12352211
• NACRES: NA.25

Właściwości

• opis: 7α-hydroxy-4-cholesten-3-one
• Próba: >99% (TLC)
• Formularz: powder
• opakowanie: pkg of 1 × 1 mg (700113P-1mg); pkg of 1 × 10 mg (700113P-10mg)
• producent / nazwa handlowa: Avanti Research^™ - A Croda Brand
• Warunki transportu: dry ice
• temp. przechowywania: −20°C
• InChI: 1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1
• Klucz InChI: IOIZWEJGGCZDOL-RQDYSCIWSA-N

Opis

Opis ogólny

7α-Hydroxy-4-cholesten-3-one is an intermediate in the biochemical synthesis of bile acids from cholesterol. Its precursor, 7α-hydroxycholesterol, is produced from cholesterol by hepatic cholesterol 7α-hydroxylase (CYP7A1).[1]It is metabolized by the enzyme 7α-hydroxycholest-4-en-3-one 12α-hydroxylase to 7α,12α-dihydroxycholest-4-en-3-one and then to cholic acid, the major primary bile acid in humans. Alternatively, it can be converted into 5β-cholestane-3α,7α-diol and then to chenodeoxycholic acid, the other major primary bile acid in humans.Serum 7α-hydroxy-4-cholesten-3-one concentrations reflect the activity of the bile acid synthetic pathway. Serum 7α-hydroxy-4-cholesten-3-one values vary during the day as bile acid synthetic rates have a diurnal rhythm.[2]Elevated values are found in patients with bile acid malabsorption and may be useful in the diagnosis of this condition as high values are associated with low SeHCAT retention.[3] The increase in serum 7α-hydroxy-4-cholesten-3-one concentrations reflects the loss of bile acids secondary to bile acid malabsorption or the increased synthesis found in primary bile acid diarrhea associated with impaired negative feedback of CYP7A1 by FGF19.[4]

Zastosowanie

• Role as a mediator in cholesterol metabolism: 7α-hydroxycholestenone has been implicated in the discussion on oxysterols as cholesterol metabolites that act as significant mediators within biological systems, highlighting its importance in cholesterol metabolism and potential pharmaceutical implications (Mutemberezi et al., 2016).

Opakowanie

5 mL Amber Glass Screw Cap Vial (700113P-10mg)

5 mL Amber Glass Screw Cap Vial (700113P-1mg)

Informacje prawne

Avanti Research is a trademark of Avanti Polar Lipids, LLC

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable