QBD10552

MAL-dPEG^®₈-TFP ester

• Synonim(y): Polyethylene glycol
• Wzór empiryczny (zapis Hilla): C₃₂H₄₄F₄N₂O₁₃
• Masa cząsteczkowa: 740.69
• Numer MDL: MFCD28505514
• Kod UNSPSC: 12352108
• Identyfikator substancji w PubChem: 329823941
• NACRES: NA.22

Właściwości

• Próba: >90%
• Postać: solid or viscous liquid
• przydatność reakcji: reactivity: thiol reactive; reagent type: cross-linking reagent; reactivity: amine reactive
• grupa funkcyjna: ester; maleimide
• architektura polimerowa: shape: linear; functionality: heterobifunctional
• Warunki transportu: ambient
• temp. przechowywania: −20°C
• ciąg SMILES: O=C(OC1=C(F)C(F)=CC(F)=C1F)CCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCN2C(C=CC2=O)=O)=O

Opis

Cechy i korzyści

MAL-dPEG^®₈-TFP ester is a heterobifunctional, linear crosslinking reagent containing a maleimide group on one end of the single molecular weight dPEG^® spacer arm and an amine-reactive active ester on the other end. The maleimide group reacts readily and specifically with free sulfhydryl groups in aqueous media at pH 6.5-7.5. The 2,3,5,6-tetrafluorophenyl (TFP) ester is used widely in reactions with primary amines. The TFP-amine reactions can be carried out in aqueous or organic solvent. The dPEG^® spacer is hydrophilic and non-immunogenic. Because it is a single molecular weight product, it gives the user precise spatial control. The dPEG^® spacer also improves water solubility, decreases immunogenicity, and increases the hydrodynamic volume of the conjugate. The increased hydrodynamic volume results in longer serum half-life in vivo.

Informacje prawne

Products Protected under U.S. Patents # 7,888,536 B2

dPEG is a registered trademark of Quanta BioDesign

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable