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Merck
모든 사진(4)

Key Documents

D9163

Sigma-Aldrich

DL-Dithiothreitol

suitable for electrophoresis, ≥99%

동의어(들):

threo-1,4-Dimercapto-2,3-butanediol, Cleland’s reagent, DTT

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About This Item

Linear Formula:
HSCH2CH(OH)CH(OH)CH2SH
CAS Number:
Molecular Weight:
154.25
Beilstein:
1719757
EC Number:
MDL number:
UNSPSC 코드:
12161504
PubChem Substance ID:
NACRES:
NB.22

Quality Level

분석

≥99%

형태

powder

반응 적합성

reagent type: reductant

기술

electrophoresis: suitable

mp

40-44 °C
41-44 °C (lit.)

solubility

H2O: 50 mg/mL, clear, colorless to very faintly yellow

양이온 미량물

heavy metals (as Pb): ≤10 ppm

흡수

≤0.04 at 280 at 0.02 M

저장 온도

2-8°C

SMILES string

O[C@H](CS)[C@H](O)CS

InChI

1S/C4H10O2S2/c5-3(1-7)4(6)2-8/h3-8H,1-2H2/t3-,4-/m1/s1

InChI key

VHJLVAABSRFDPM-QWWZWVQMSA-N

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애플리케이션

An excellent reagent for maintaining SH groups in reduced state; quantitatively reduces disulfides. DTT is effective in sample buffers for reducing protein disulfide bonds prior to SDS-PAGE. DTT can also be used for reducing the disulfide bridge of the cross-linker N,N′-bis(acryloyl)cystamine to break apart the matrix of a polyacrylamide gel. DTT is less pungent and is less toxic than 2-mercaptoethanol. Typically, a seven fold lower concentration of DTT (100 mM) is needed than is used for 2-mercaptoethanol (5% v/v, 700 mM).

분석 메모

Tested for use in reduced SDS-PAGE

픽토그램

CorrosionExclamation mark

신호어

Danger

유해 및 위험 성명서

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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