SRP8045

CD40L, Soluble mouse

recombinant, expressed in CHO cells, FLAG^® tagged, >95% (SDS-PAGE)

• 別名: ACRP30headless:CD154, ACRP30headless:CD40L, ACRP30headless:TNFSF5, ADIPOQ-CD40L
• UNSPSCコード: 12352200
• NACRES: NA.32

特性

• 由来生物: mouse
• リコンビナント: expressed in CHO cells
• タグ: FLAG^® tagged
• アッセイ: >95% (SDS-PAGE)
• 形状: lyophilized
• 分子量: 35-40 kDa
• 包装: pkg of 10 μg
• 保管条件: avoid repeated freeze/thaw cycles
• 不純物: <0.01 EU/μg endotoxin, tested
• UniProtアクセッション番号: P27548
• 輸送温度: wet ice
• 保管温度: −20°C
• 遺伝子情報: mouse ... Cd40lg(21947)

詳細

詳細

CD40L (cluster of differentiation 40 ligand), a member of TNF (tumor necrosis factor) superfamily, is a membrane bound protein. This protein is predominantly expressed transiently by activated CD4⁺ T cells either as a cell-surface molecule or a secreted multimer protein. Activated B cells, certain DC (dendritic cell) subsets, platelets, and smooth muscle cells also express this protein.

生物化学的／生理学的作用

CD40L (cluster of differentiation 40 ligand) interacts with its receptor CD40 which in turn helps mediate the interaction between APCs (antigen presenting cells) and lymphocytes. Activated platelets produce CD40L which then participates in multiple processes such as endothelial cell reactions, formation of germinal center, T-helper cell priming, and cytotoxic T-cell activation. Platelets are also involved in the pathogenesis of asthma through CD40L where they inhibit the production of regulatory T-cells and promote polarization of T-helper cells. Studies in mice show that this protein confers protection against influenza virus, though in a CD4⁺ T cell independent manner.

物理的形状

凍結乾燥品(PBS)。

再構成

Reconstitute with 100 μL deionized water.

その他情報

Mouse CD40L (aa 115-260) is fused at the N-terminus to mouse ACRP30headless (aa 18-111) and a FLAG^®-tag.

法的情報

FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable