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Amino Acid Sequence
H-THR-LEU-GLN-PRO-PRO-SER-ALA-LEU-ARG-ARG-ARG-HIS-TYR-HIS-HIS-ALA-LEU-PRO-PRO-SER-ARG-OH
詳細
TLQP-21 peptide is a derivative of VGF and is expressed at higher levels in the brain.
生物化学的/生理学的作用
TLQP-21 peptide is involved in the central and peripheral nervous system activities such as regulating reproductive and circadian behaviors, feeding, and body weight. It is also involved in regulating neuropathic pain and peripheral adiposity. TLQP-21 plays a role in stimulating the secretion of insulin and prevents apoptosis of pancreatic cells. It also activates the complement C3a receptor-1 (C3aR1) in the brain.
物理的形状
Lyophilized from 0.1% aqueous TFA
その他情報
Lyophilized from 0.1% TFA in H2O
保管分類コード
11 - Combustible Solids
WGK
WGK 3
適用法令
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Jan Code
T1081-0.5MG-PW:
T1081-1MG:
T1081-0.5MG:
T1081-VAR:
T1081-BULK:
T1081-1MG-PW:
試験成績書(COA)
製品のロット番号・バッチ番号を入力して、試験成績書(COA) を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
PloS one, 8(11), e79760-e79760 (2013-11-28)
Hyperglycemia causes oxidative stress that could damage vascular endothelial cells, leading to cardiovascular complications. The Vgf gene was identified as a nerve growth factor-responsive gene, and its protein product, VGF, is characterized by the presence of partially cleaved products. One
British journal of pharmacology, 157(6), 984-993 (2009-05-27)
Vgf gene expression has been detected in various endocrine and neuronal cells in the gastrointestinal tract. In this study we investigated the pharmacological activity of different VGF-derived peptides. Among these, TLQP-21, corresponding to the 556-576 fragment of the protein was
Proceedings of the National Academy of Sciences of the United States of America, 103(39), 14584-14589 (2006-09-20)
The vgf gene has been identified as an energy homeostasis regulator. Vgf encodes a 617-aa precursor protein that is processed to yield an incompletely characterized panel of neuropeptides. Until now, it was an unproved assumption that VGF-derived peptides could regulate
Autophagy, 16(12), 2140-2155 (2020-01-22)
Mesenchymal stem cell (MSC) transplantation has been widely applied as a potential therapeutic for multiple diseases. However, the underlying therapeutic mechanisms are not fully understood, especially the paradox between the low survival rate of transplanted cells and the beneficial therapeutic
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