SML2992

uPSEM792 hydrochloride

≥98% (HPLC)

• 別名: 1-Methyl-7,8,9,10-tetrahydro-1H-6,10-methanoazepino[4,5-g]quinoxalin-2(6H)-one hydrochloride, PSEM 792 hydrochloride
• 実験式（ヒル表記法）: C₁₄H₁₅N₃O · HCl
• CAS番号: 2341841-08-3
• 分子量: 277.75
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 保管条件: desiccated
• 色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear
• 保管温度: 2-8°C
• SMILES記法: O=C1N(C)C2=CC(C3CNCC4C3)=C4C=C2N=C1.Cl
• InChI Key: CDHPEJUYEXNGCV-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

Ultrapotent PSEM agonist for chimeric ligand-gated ion channel pores with nAChR α7 LBD L181G/Q139L/Y217F mutant (PSAM4) in vitro and in vivo.

uPSEM792 is a selective and ultrapotent pharmacologically selective effector molecule (uPSEM) agonist for chimeric pharmacologically selective actuator modules (PSAMs) with mutant nAChR α7 ligand-binding domain (LBD) PSML181G/Q139L/Y217F (PSAM4) fused to the ion pore domain (IPD) of ligand-gated ion channels (LGICs), including glycine receptor (PSAM4-GlyR EC50 = 2.3 nM) and 5-HT3 (PSAM4-5-HT3 EC50 = 1.6 nM). uPSEM792 exhibits high PSM4 selectivity (>10,000-fold over α7-GlyR, α7-5HT3, 5HT3; >230-fold over α4β2 nAChR) and sub-nanomolar PSAM4-GlyR affinity (Ki = 0.7 nM).

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable