PZ0116

PD-166285 水和物

≥98% (HPLC)

• 別名: 6-(2,6-ジクロロフェニル)-2-[[4-[2-(ジエチルアミノ)エトキシ]フェニル]アミノ]-8-メチル-ピリド[2,3-d]ピリミジン-7(8H)-オン 二塩酸塩 水和物
• 実験式（ヒル表記法）: C₂₆H₂₇Cl₂N₅O₂·2HCl
• 分子量: 585.35
• MDL番号: MFCD17215957
• UNSPSCコード: 51111800
• PubChem Substance ID: 329823708
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• 形状: powder
• 色: yellow
• 溶解性: DMSO: ≥20 mg/mL; H₂O: ≥5 mg/mL
• 保管温度: room temp
• SMILES記法: O.Cl.Cl.CCN(CC)CCOc1ccc(Nc2ncc3C=C(C(=O)N(C)c3n2)c4c(Cl)cccc4Cl)cc1
• InChI: 1S/C26H27Cl2N5O2.2ClH.H2O/c1-4-33(5-2)13-14-35-19-11-9-18(10-12-19)30-26-29-16-17-15-20(25(34)32(3)24(17)31-26)23-21(27)7-6-8-22(23)28;;;/h6-12,15-16H,4-5,13-14H2,1-3H3,(H,29,30,31);2*1H;1H2
• InChI Key: FHIIMEXCWLFXBU-UHFFFAOYSA-N

詳細

アプリケーション

PD-166285 Hydrate has been used as a fibroblast growth factor (FGF) signaling inhibitor to study its effects on LIM-homeodomain gene 9 (Lhx9) expression during limb development in mice.

生物化学的／生理学的作用

PD-166285 is also a potent inhibitor of Wee-1, epidermal growth factor receptor, and platelet-derived growth factor receptor β subunit (PDGFR-β). It also exhibits its inhibitory effects against mitogen-activated protein kinase (MAPK) and protein kinase C (PKC). PD-166285 shows antiproliferative and anti-migratory effects due to which it may be used as a therapeutic agent against atherosclerosis, restenosis, and cancer.

PD-166285水和物は、広域スペクトルのプロテインチロシンキナーゼインヒビターであり、Src、FGFRを阻害します。

特徴および利点

This compound is featured on the FGFR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全性情報

• ピクトグラム: GHS06
• シグナルワード: Danger
• 危険有害性情報: H301,H413
• 注意書き: P264 - P270 - P273 - P301 + P310 - P405 - P501
• 危険有害性の分類: Acute Tox. 3 Oral - Aquatic Chronic 4
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable