5.08225

(Z)-4-Hydroxytamoxifen

InSolution, ≥99%

• 別名: InSolution Tamoxifen, 4-Hydroxy-, ( Z)-, ( Z)-4-(1-(4-(Dimethylaminoethoxy)phenyl)-2-phenyl-1-butenyl)phenol, ( Z)-4-(1-(4-(2-(Dimethylamino)ethoxy)phenyl)-2-phenylbut-1-enyl)phenol, (Z)-4-Hydroxytamoxifen, (Z)-4-OH-TAM, trans-4-Hydroxytamoxifen
• 実験式（ヒル表記法）: C₂₆H₂₉NO₂
• CAS番号: 68047-06-3
• 分子量: 387.51
• MDL番号: MFCD00278780
• UNSPSCコード: 12352200

特性

• 品質水準: 100
• アッセイ: ≥99% (HPLC)
• 形状: liquid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; avoid repeated freeze/thaw cycles; desiccated (hygroscopic); protect from light
• 保管温度: −70°C
• InChI: 1S/C26H29NO2/c1-4-25(20-10-14-23(28)15-11-20)26(21-8-6-5-7-9-21)22-12-16-24(17-13-22)29-19-18-27(2)3/h5-17,28H,4,18-19H2,1-3H3/b26-25-
• InChI Key: DODQJNMQWMSYGS-QPLCGJKRSA-N

詳細

詳細

A 10 mM (2 mg/516 µL) sterile-filtered solution of (Z)-4-Hydroxytamoxifen in ethanol.

A cell-permeable, active metabolite of Tamoxifen (Cat. No. 579000) that acts as a potent inhibitor of PKC. It is more potent than the parent compound and inhibits PKC by modifying its catalytic domain.

生物化学的／生理学的作用

Cell permeable: yes

Primary Target
Estrogen receptor

警告

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

物理的形状

A 10 mM (2 mg/516 µL) sterile-filtered solution of (Z)-4-Hydroxytamoxifen (Cat. No. 579002) in EtOH.

再構成

Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C. Use only anhydrous, 200 proof ethanol for further dilutions.

その他情報

Gundimeda, U., et al. 1996. J. Biol. Chem.271, 13504.
Ye, Q. and Bodell, W.J. 1996. Carcinogenesis17, 1747.
Laser, R., et al. 1985. Eur. J. Cancer Clin. Oncol.21, 985.
Jordan, V.C., et al. 1978. J. Toxicol. Environ. Health4, 364.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS02,GHS07,GHS08
• シグナルワード: Danger
• 危険有害性情報: H225 - H319 - H350 - H360FD - H412
• 注意書き: P202 - P210 - P233 - P273 - P305 + P351 + P338 - P308 + P313
• 危険有害性の分類: Aquatic Chronic 3 - Carc. 1B - Eye Irrit. 2 - Flam. Liq. 2 - Repr. 1B
• 保管分類コード: 3 - Flammable liquids
• WGK: WGK 3
• 引火点(°F): 55.4 °F
• 引火点(℃): 13 °C