SML2490

APC366 trifluoroacetate

≥97% (HPLC)

• 別名: APC 366 trifluoroacetate, N-(1-Hydroxy-2-naphthoyl)-L-arginyl-L-prolinamide, N2-[(1-Hydroxy-2-naphthalenyl)carbonyl]-L-arginyl-L-prolinamide trifluoroacetate
• 実験式（ヒル表記法）: C₂₂H₂₈N₆O₄ · xC₂HF₃O₂
• CAS番号: 158921-85-8
• 分子量: 440.50 (free base basis)
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• アッセイ: ≥97% (HPLC)
• フォーム: lyophilized powder
• 色: white to off-white
• 輸送温度: wet ice
• 保管温度: −20°C
• SMILES記法: FC(F)(C(O)=O)F.NC(NCCC[C@@H](C(N1CCC[C@H]1C(N)=O)=O)NC(C2=C(O)C3=CC=CC=C3C=C2)=O)=N
• InChI: 1S/C22H28N6O4/c23-19(30)17-8-4-12-28(17)21(32)16(7-3-11-26-22(24)25)27-20(31)15-10-9-13-5-1-2-6-14(13)18(15)29/h1-2,5-6,9-10,16-17,29H,3-4,7-8,11-12H2,(H2,23,30)(H,27,31)(H4,24,25,26)/t16-,17-/m0/s1
• InChI Key: SKYWIMYOGAWOMB-IRXDYDNUSA-N

詳細

生物化学的／生理学的作用

APC366 is a selective inhibitor of mast cell tryptase, which is involved with allergenic response. It thereby also inhibits protease-activated receptor PAR2, a G-protein-coupled receptor that is activated by mast cell tryptase. Tryptase has been proposed to be involved in fibrosis, joint inflammation and also in promoting breast cancer angiogenesis, all of which APC366 inhibited.