SML1103

Entecavir

≥98% (HPLC)

• 別名: 2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one, 2-Amino-9-[(1S,3R,4S)-4-hydroxy-3-hydroxymethyl-2-methylene-cyclopentyl]-3,9-dihydro-purin-6-one, BMS 200475, SQ 34,676
• 実験式（ヒル表記法）: C₁₂H₁₅N₅O₃
• CAS番号: 142217-69-4
• 分子量: 277.28
• MDL番号: MFCD11046562
• UNSPSCコード: 51111800
• PubChem Substance ID: 329825478
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 光学活性: [α]/D +25 to +40°, c = 0.2 in H₂O
• 保管条件: desiccated
• 色: white to beige
• 溶解性: H₂O: 0.5 mg/mL, clear (warmed)
• 保管温度: −20°C
• SMILES記法: O=C1C2=C(N([C@H]3C[C@H](O)[C@@H](CO)C3=C)C=N2)NC(N)=N1
• InChI: 1S/C12H15N5O3/c1-5-6(3-18)8(19)2-7(5)17-4-14-9-10(17)15-12(13)16-11(9)20/h4,6-8,18-19H,1-3H2,(H3,13,15,16,20)/t6-,7-,8-/m0/s1
• InChI Key: QDGZDCVAUDNJFG-FXQIFTODSA-N

詳細

生物化学的／生理学的作用

Entecavir is an antiviral guanine analog that inhibits reverse transcription, DNA replication and transcription in the viral replication process. Entecavir is used to treat hepatitis B.

Entecavir is an antiviral guanine analog that inhibits reverse transcription, DNA replication and transcription.

Entecavir is used as an effective drug to treat lamivudine-refractory patients with chronic hepatitis B virus (CHB) at a dose of 1 mg daily.

安全性情報

• ピクトグラム: GHS08,GHS07
• シグナルワード: Warning
• 危険有害性情報: H302,H351
• 注意書き: P202 - P264 - P270 - P280 - P301 + P312 - P308 + P313
• 危険有害性の分類: Acute Tox. 4 Oral - Carc. 2
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable