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詳細
IFN-α-2a belongs to the type I interferon protein family. Interferon α 2A is one among the three variants of IFN-α2. Recombinant human IFN-α-2a is expressed in human 293 cells as a glycosylated monomer of 165 amino acids, with an average molecular weight of 20 kDa (monomer).
アプリケーション
Interferon α 2A human has been used as an inhibitor of hepatitis D virus (HDV).
生物化学的／生理学的作用
Interferon Alpha 2A human is produced by many cell types in response to viral infection. IFN-α-2A has antiproliferative and antitumor activities, as well as induction of apoptosis and inflammatory response
Interferon α 2A might be implicated in the regression of proliferative diabetic retinopathy. Telaprevir and pegylated interferon–α-2a (PEG-IFN–α-2a) serves as a potential therapeutic method for hepatitis C virus (HCV). IFN α 2A along with IFN α 2b and IFN α2c exhibits anti-proliferative effect.
Interferon α 2A might be implicated in the regression of proliferative diabetic retinopathy. Telaprevir and pegylated interferon–α-2a (PEG-IFN–α-2a) serves as a potential therapeutic method for hepatitis C virus (HCV). IFN α 2A along with IFN α 2b and IFN α2c exhibits anti-proliferative effect.
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
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Telaprevir and pegylated interferon?alpha?2a inhibit wild?type and resistant genotype 1 hepatitis C virus replication in patients
Kieffer T L, et al.
Hepatology, 46(3), 631-639 (2007)
Interferon alpha-2a for proliferative diabetic retinopathy after complete laser panretinal photocoagulation treatment.
Leibovitch I, et al.
Ophthalmic Surgery, Lasers & Imaging Retina, 35(1), 16-22 (2004)
Telaprevir and pegylated interferon?alpha-2a inhibit wild-type and resistant genotype 1 hepatitis C virus replication in patients.
Tara L K, et al.
Hepatology (2007)
Antitumor activities of interferon alpha, beta, and gamma and their combinations on human melanoma cells in vitro: changes of proliferation, melanin synthesis, and immunophenotype
Garbe C, et al.
The Journal of Investigative Dermatology, 95-95 (1990)
Antitumor activities of interferon alpha, beta, and gamma and their combinations on human melanoma cells in vitro: changes of proliferation, melanin synthesis, and immunophenotype.
Garbe C, et al.
The Journal of Investigative Dermatology, 95(6), 231S-237S (1990)
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