おすすめの製品
由来生物
human
リコンビナント
expressed in E. coli
アッセイ
≥95% (HPLC)
≥95% (SDS-PAGE)
形状
lyophilized
有効性
1x10^8 units/mg
分子量
~19.3 kDa
包装
pkg of 100 μg
保管条件
avoid repeated freeze/thaw cycles
不純物
endotoxin, tested
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
wet ice
保管温度
−20°C
遺伝子情報
human ... IFNA1(3439)
詳細
IFN-α1 (interferon α 1) is a type 1 interferon. Human IFN-a1 is a 19.3kDa protein containing 166 amino acid residues. IFN-α1 belongs to the type I interferon (IFN) family and is present in leukocytes. The IFN-α1 gene is mapped to human chromosome 9p21.3.
アプリケーション
IFN-alpha 1 human has been used:
- to treat Vero and breast cancer (MDA-MB-231) cells in interferon assay before viral infection
- as a ligand to vaccinia virus B18R protein in analytical size exclusion chromatography
- to treat chikungunya infected human embryonic kidney cell line (HEK293T) to test its effect on Signal transducer and activator of transcription 1 (STAT1) phosphorylation
- as recombinant interferon to treat lung fibroblast cell line (IMR90) to monitor histone chaperone (HIRA) response
生物化学的／生理学的作用
IFN-α1 (interferon α 1) is a lymphoid factor that possesses potent anti-viral activity. IFN-α1 interacts with IFNAR1 (interferon α receptor 1) and IFNAR2. The interaction activates JAK1 (janus-activated kinase 1) and tyrosine kinase 2. These events phosphorylate and activate STAT1 and STAT2 (signal transducer and activator of transcription proteins), leading to the upregulation of interferon-stimulated genes some of which encode antiviral proteins. IFN-alpha 1 (IFN-α1) mediates apoptosis in specific tissues. It may be useful in treating laryngeal carcinoma. The interaction of microRNA, miR-181b with IFN-α1, is regarded as a risk factor in systemic lupus erythematosus.
物理的形状
凍結乾燥品(添加物不含)。
再構成
バイアルは、開封前に遠心してください。凍結融解の繰り返しは避けてください。
Reconstitute in water to a concentration of 0.1-1 mg/mL. This solution can then be diluted into other aqueous buffers.
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
PRTR
第一種指定化学物質
Jan Code
SRP4596-100UG:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
この製品を見ている人はこちらもチェック
Rajani Rajbhandari et al.
Oncotarget, 6(19), 17805-17816 (2015-07-15)
Glioblastomas (GBMs) are deadly tumors of the central nervous system. Most GBM exhibit homozygous deletions of the CDKN2A and CDKN2B tumor suppressors at 9p21.3, although loss of CDKN2A/B alone is insufficient to drive gliomagenesis. MIR31HG, which encodes microRNA-31 (miR-31), is
Purification and characterization of multiple components of human lymphoblastoid interferon-alpha.
Zoon KC, et al.
The Journal of Biological Chemistry, 267, 15210-15216 (1992)
Marina Juraleviciute et al.
Cancer medicine, 10(8), 2840-2854 (2021-03-19)
MX2 is an interferon inducible gene that is mostly known for its antiviral activity. We have previously demonstrated that MX2 is also associated with the tumorigenesis process in melanoma. However, it remains unknown which molecular mechanisms are regulated by MX2
Saisai Wang et al.
Journal of cellular and molecular medicine, 19(10), 2432-2440 (2015-06-30)
Src homology phosphotyrosyl phosphatase 2 (Shp-2) is a ubiquitously expressed protein that is involved in a variety of cellular processes, including antiviral interferon signalling pathways. In this study, we investigated the role of Shp-2 in the host cell interactions of
Xing Liu et al.
Journal of virology, 93(2) (2018-11-09)
Oncolytic herpes simplex virus 1 (HSV-1), devoid of the γ134.5 gene, exerts antitumor activities. However, the oncolytic effects differ, ranging from pronounced to little responses. Although viral and host factors are involved, much remains to be deciphered. Here we report
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
製品に関するお問い合わせはこちら（テクニカルサービス）