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リコンビナント
expressed in HEK 293 cells
品質水準
抗体製品の状態
purified immunoglobulin
抗体製品タイプ
primary antibodies
クローン
RM179, monoclonal
recombinant monoclonal
形状
buffered aqueous glycerol solution
化学種の反応性
human
濃度
~1 mg/mL
テクニック
ELISA: 0.5-1 μg/mL
immunocytochemistry: 0.5-2 μg/mL
immunohistochemistry: 1 ug/mL – 10 ug/mL
western blot: 1-2 μg/mL
アイソタイプ
IgG
NCBIアクセッション番号
輸送温度
wet ice
保管温度
−20°C
ターゲットの翻訳後修飾
acetylation (Lys56)
遺伝子情報
human ... H3C1(8350)
詳細
Mammals contain three main classes of histone H3 variants: the replicative histones (H3.1 and H3.2), the replacement histone (H3.3) and the centromeric histone (Cenp-A). Histone H3 is located on human chromosome 6p22.
特異性
This antibody reacts to Histone H3 acetylated at Lysine 56 (K56ac). No cross reactivity with other acetylated Lysines in histone H3.
免疫原
Synthetic peptide corresponding to the Acetyl-Histone H3 (Lys56)
生物化学的／生理学的作用
Histone proteins are basic building blocks of chromatin. Histone H3 K27M mutations in adult cerebellar high-grade gliomas. It controls protein-protein interactions to induce binding of trans-acting factors that drive chromatin condensation.
特徴および利点
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
物理的形状
Solution in phosphate buffered saline containing 50% glycerol, 1% BSA and 0.09% sodium azide.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
WGK 2
引火点(°F)
Not applicable
引火点(℃)
Not applicable
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Nataliya Danilenko et al.
Nature communications, 10(1), 3435-3435 (2019-08-08)
Histones, the principal protein components of chromatin, contain long disordered sequences, which are extensively post-translationally modified. Although histone chaperones are known to control both the activity and specificity of histone-modifying enzymes, the mechanisms promoting modification of highly disordered substrates, such
Signaling to chromatin through histone modifications.
Cheung P, et al.
Cell, 103(2), 263-271 (2000)
Histone H3 K27M mutations in adult cerebellar high-grade gliomas.
Nakata S, et al.
Brain Tumor Pathology, 34(3), 113-119 (2017)
The program for processing newly synthesized histones H3.1 and H4.
Campos EI
Nature Structural and Molecular Biology, 17(11), 1343-1351 (2010)
A comprehensive view of the epigenetic landscape part I: DNA methylation, passive and active DNA demethylation pathways and histone variants.
Sadakierska-Chudy A
Neurotoxicity Research, 27(1), 84-97 (2015)
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