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由来生物
rabbit
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
形状
buffered aqueous solution
分子量
antigen 8 kDa
化学種の反応性
mouse, rat, human
濃度
~1 mg/mL
テクニック
ELISA: 1:20000
immunohistochemistry: 1:50-1:100
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
wet ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... UBA52(7311)
詳細
Anti-Ubiquitin Antibody detects endogenous levels of total Ubiquitin protein.
Ribosomal protein S27a (RPS27A), also known as ubiquitin carboxyl extension protein 1 (UBCEP-1), is a ribosomal protein, which is naturally synthesized as an ubiquitin (Ub) C-terminal extension protein. The protein is encoded by RPS27A gene mapped to human chromosome 2p16. RPS27 is a 9.8kDa protein characterized with one zinc finger domain in its monomeric state.
免疫原
The antiserum was produced against synthesized peptide derived from human Ubiquitin.
Immunogen Range: 40-89
Immunogen Range: 40-89
アプリケーション
Anti-Ubiquitin antibody produced in rabbit has been used in following assays:
- Western blot analysis.
- Immunofluorescence-proximity ligation assay (IF-PLA).
- Immunofluorescence.
生物化学的／生理学的作用
Ribosomal protein S27a (RPS27a) is involved in ribosome biogenesis and post-translational modifications of proteins. The encoded protein enhances cell proliferation, controls cell cycle progression, and inhibits apoptosis of leukemia cells. Overexpression of RPS27A or ubiquitin results in advanced-phase chronic myeloid leukemia (CML) and acute leukemia (AL). Hence drugs targeting RPS27a combining with tyrosine kinase inhibitor (TKI) might be a potential treatment for TKI resistant CML patients. Elevated expression of ubiquitin carboxyl extension protein 1 (UBCEP-1), which is a component of ubiquitin pathway, promotes prostate carcinoma development, via increasing the degradation of proteins involved in growth inhibition or apoptosis. RPS27a might act as a unique stress sensor in cells, which results in increased p53 activity leading to inhibition of cell cycle progression.
特徴および利点
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
物理的形状
ウサギIgGのPBS溶液（Mg2+およびCa2+を含まず）、pH 7.4、150 mM NaCl、0.02％ アジ化ナトリウム、50％ グリセロール
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
nwg
引火点(°F)
Not applicable
引火点(℃)
Not applicable
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
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Houcai Wang et al.
Oncotarget, 7(14), 18638-18650 (2016-03-05)
STAT3 plays a pivotal role in the hematopoietic system, which constitutively activated by BCR-ABL via JAK and Erk/MAP-kinase pathways. Phospho-STAT3 was overexpressed in imatinib-resistant CML patients as relative to imatinib responsive ones. By activation of the STAT3 pathway, BCR-ABL can
Nicholas S Caron et al.
Human molecular genetics, 23(9), 2324-2338 (2013-12-18)
Huntington's disease (HD) is an autosomal dominant, neurodegenerative disorder that can be characterized by the presence of protein inclusions containing mutant huntingtin within a subset of neurons in the brain. Since their discovery, the relevance of inclusions to disease pathology
Nagisa Nosrati et al.
Gene, 559(1), 44-51 (2015-01-17)
The small ribosomal protein RPS27a is known to play a role in the activation of cellular checkpoints via p53 which links ribosome biogenesis to cell cycle progression. Here, we show that RPS27a gene is a direct transcriptional target of p53
Santhosh Kumar Sariki et al.
The FEBS journal, 283(22), 4056-4083 (2016-10-26)
Mutations in the Senataxin gene, SETX are known to cause the neurodegenerative disorders, ataxia with oculomotor apraxia type 2 (AOA2), and amyotrophic lateral sclerosis 4 (ALS4). However, the mechanism underlying disease pathogenesis is still unclear. The Senataxin N-terminal protein-interaction and
Houcai Wang et al.
Biochemical and biophysical research communications, 446(4), 1204-1210 (2014-04-01)
Ribosomal protein S27a (RPS27a) could perform extra-ribosomal functions besides imparting a role in ribosome biogenesis and post-translational modifications of proteins. The high expression level of RPS27a was reported in solid tumors, and we found that the expression level of RPS27a
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