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由来生物
rabbit
品質水準
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
形状
buffered aqueous solution
分子量
antigen 116 kDa
化学種の反応性
human, mouse, rat
濃度
~1 mg/mL
テクニック
ELISA: 1:1000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
wet ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... LIPE(3991)
詳細
Human hormone-sensitive lipase (HSL) gene, containing 9 exons and spanning ~11kB, is mapped to chromosome 19q13.3. HSL is majorly expressed in adipose and steroidogenic tissues, but expressed at low levels in heart and skeletal muscle, macrophages, and islets. Functional HSL exists as a homodimer with high hydrolytic activity. HSL is characterized with a C-terminal catalytic domain, regulatory module and an N-terminal domain responsible for protein–protein and protein–lipid interactions.
免疫原
The antiserum was produced against synthesized peptide derived from human HSL.
Immunogen Range: 520-569
Immunogen Range: 520-569
生物化学的／生理学的作用
Hormone-sensitive lipase (HSL) is the major source of energy for most of the tissues. It plays a vital role in hydrolysis of triacylglycerol stored in adipose tissue and possibly steroidogenesis. HSL activity is regulated through reversible phosphorylation by catecholamines and insulin. HSL, also hydrolyzes cholesterol esters in the adrenals, ovaries, testes, and macrophages and plays an essential role in spermatogenesis. HSL mRNA expressed in islets might be implicated in glucose-induced insulin secretion. Abnormality in the protein expression results in obesity, atherosclerosis and type II diabetes.
特徴および利点
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
物理的形状
ウサギIgGのPBS溶液（Mg2+およびCa2+を含まず）、pH 7.4、150 mM NaCl、0.02％ アジ化ナトリウム、50％ グリセロール
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
nwg
引火点(°F)
Not applicable
引火点(℃)
Not applicable
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Stephen J Yeaman
The Biochemical journal, 379(Pt 1), 11-22 (2004-01-17)
Although described initially as an intracellular adipocyte-specific triacylglycerol lipase, it is now clear that HSL (hormone-sensitive lipase) is expressed in multiple tissues and plays a number of roles in lipid metabolism, including that of a neutral cholesteryl ester hydrolase. The
Wucai Yang et al.
Scientific reports, 7(1), 15080-15080 (2017-11-10)
Melatonin (N-acetyl-5-methoxytryptamine) is a derivative of tryptophan which is produced and secreted mainly by the pineal gland and regulates a variety of important central and peripheral actions. To examine the potential effects of melatonin on the proliferation and differentiation of
Fredric B Kraemer et al.
Journal of lipid research, 43(10), 1585-1594 (2002-10-05)
Hormone-sensitive lipase (HSL) is an intracellular neutral lipase that is capable of hydrolyzing triacylglycerols, diacylglycerols, monoacylglycerols, and cholesteryl esters, as well as other lipid and water soluble substrates. HSL activity is regulated post-translationally by phosphorylation and also by pretranslational mechanisms.
C Holm et al.
Science (New York, N.Y.), 241(4872), 1503-1506 (1988-09-16)
Hormone-sensitive lipase, a key enzyme in fatty acid mobilization, overall energy homeostasis, and possibly steroidogenesis, is acutely controlled through reversible phosphorylation by catecholamines and insulin. The 757-amino acid sequence predicted from a cloned rat adipocyte complementary DNA showed no homology
J Osuga et al.
Proceedings of the National Academy of Sciences of the United States of America, 97(2), 787-792 (2000-01-19)
Hormone-sensitive lipase (HSL) is known to mediate the hydrolysis not only of triacylglycerol stored in adipose tissue but also of cholesterol esters in the adrenals, ovaries, testes, and macrophages. To elucidate its precise role in the development of obesity and
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