S9701

スルバクタム

• 別名: (2S,5R)-3,3-ジメチル-7-オキソ-4-チア-1-アザビシクロ[3.2.0]ヘプタン-2-カルボン酸 4,4-ジオキシド, Betamaze, CP 45899, CP-45,899, ペニシラン酸 1,1-ジオキシド, ペニシラン酸 S,S-ジオキシド, ペニシラン酸 ジオキシド, ペニシラン酸 スルホン
• 実験式（ヒル表記法）: C₈H₁₁NO₅S
• CAS番号: 68373-14-8
• 分子量: 233.24
• EC Number: 269-878-2
• MDL番号: MFCD00867005
• UNSPSCコード: 12352200
• PubChem Substance ID: 329824632
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• 形状: powder
• 光学活性: [α]/D ≥+225°, c = 1 in H₂O
• 色: white to tan
• 溶解性: H₂O: ≥18 mg/mL
• 保管温度: 2-8°C
• SMILES記法: CC1(C)[C@@H](N2[C@@H](CC2=O)S1(=O)=O)C(O)=O
• InChI: 1S/C8H11NO5S/c1-8(2)6(7(11)12)9-4(10)3-5(9)15(8,13)14/h5-6H,3H2,1-2H3,(H,11,12)/t5-,6+/m1/s1
• InChI Key: FKENQMMABCRJMK-RITPCOANSA-N

詳細

詳細

Sulbactam is a semi-synthetic penicillinate sulfone derived from 6-aminopenicllanic acid. This β-lactam compound is characterized by a β-lactam ring.

アプリケーション

Sulbactam has been used as a β-Lactamase inhibitor in β-lactamase inhibitor assay. It has also been used to evaluate its antimicrobial pharmacodynamic effects against extremely drug-resistant Acinetobacter baumannii. Sulbactam may be used in cell signaling studies.

生物化学的／生理学的作用

Sulbactam acts as an irreversible inhibitor of β-lactamases that inactivate β-lactams such as penicillin and cephalosporin. It is also active against bacteroides and certain chromosomally mediated enzymes of Gram-negative bacteria. It exhibits limited antimicrobial activity. However, sulbactam in combination with other potential antibiotics exhibits therapeutic effects against multidrug-resistant Acinetobacter baumannii infections.

安全性情報

• ピクトグラム: GHS08
• シグナルワード: Danger
• 危険有害性情報: H317,H334
• 注意書き: P261 - P272 - P280 - P284 - P302 + P352 - P333 + P313
• 危険有害性の分類: Resp. Sens. 1 - Skin Sens. 1
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable