PZ0250

PF-04859989 hydrochloride

≥98% (HPLC)

• 別名: (3S)-3-Amino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one; L-3-Amino-3,4-dihydro-1-hydroxycarbstyril hydrochloride, PF-4859989 hydrochloride, PF04859989 hydrochloride
• 実験式（ヒル表記法）: C₉H₁₀N₂O₂ · HCl
• CAS番号: 177943-33-8
• 分子量: 214.65
• MDL番号: MFCD22419400
• UNSPSCコード: 51111800
• PubChem Substance ID: 329823792
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: powder
• 色: white to beige
• 溶解性: H₂O: 20 mg/mL, clear
• 保管温度: room temp
• SMILES記法: N[C@H]1CC2=CC=CC=C2N(O)C1=O.Cl
• InChI: 1S/C9H10N2O2.ClH/c10-7-5-6-3-1-2-4-8(6)11(13)9(7)12;/h1-4,7,13H,5,10H2;1H/t7-;/m0./s1
• InChI Key: WZOBDOKCHIUXAY-FJXQXJEOSA-N

詳細

生物化学的／生理学的作用

PF-04859989 is a brain-penetrable irreversible inhibitor of kynurenine amino transferase II (KAT II), the enzyme responsible for most of the brain synthesis of kynurenic acid, which has been implicated in several psychiatric and neurological disorders, including schizophrenia and bipolar disorder, and thought to impair cognitive function. PF-04859989 has IC₅₀ values of 23 nM for hKAT II and 263 nM for rKAT II. PF-04859989 is ~1000-fold selective for KAT II over human KAT I, KAT III, and KAT IV. PF-04859989 prevented ketamine-induced disruption of performance in memory tasks in both rodents and nonhuman primates.

特徴および利点

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安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable