N5264

モノクロナール抗ニューロフィラメント160 マウス宿主抗体

clone NN18, ascites fluid

• 別名: モノクローナル抗ニューロフィラメント中鎖抗体
• MDL番号: MFCD01322393
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: mouse
• 品質水準: 200
• 結合体: unconjugated
• 抗体製品の状態: ascites fluid
• 抗体製品タイプ: primary antibodies
• クローン: NN18, monoclonal
• 分子量: antigen 160 kDa
• 含みます: 15 mM sodium azide
• 化学種の反応性: human, pig
• テクニック: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:40 using human tissue sections; immunohistochemistry (frozen sections): suitable; western blot: suitable
• アイソタイプ: IgG1
• UniProtアクセッション番号: P07197
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: chicken ... NEFM(396206) ; human ... NEFM(4741) ; mouse ... Nefm(18040) ; rat ... Nefm(24588)

詳細

詳細

Monoclonal Anti-Neurofilament 160 (mouse IgG1 iso-type) is produced by the fusion mouse myeloma cells and splenocytes from an immunized mouse. Neurofilaments are composed of three sub-units- light NFL protein, medium NFM protein, heavy NFH protein. Along with there two other intermediate filaments are present α-internexin and peripherin. Neurofilaments are phosphoproteins.

Neurofilaments belong to the intermediate filament family and are expressed mainly in cells or tissues of neuronal origin. It is crucial for proper radial growth of axons.

特異性

Mouse monoclonal anti-neurofilament 160 antibody reacts specifically with neurofilaments of molecular weight 160,000 but does not cross react with other intermediate filament proteins.

免疫原

ブタ脊髄由来ニュ-ロフィラメント。

アプリケーション

Monoclonal anti-neurofilament 160 antibody (diluted 1: 5000) can be used as internal loading controls in immunoblotting. It can also be used in whole-mount immunohistochemistry and western blot. Monoclonal anti-neurofilament 160 antibodies can be used for localization of neurofilaments of molecular weight 160,000 in cultured cells or tissues preparation.

Monoclonal anti-neurofilament 160 antibody has been used in

• Immunoblotting.
• Immunohistochemistry
• Immunofluorescence

生物化学的／生理学的作用

Neurofilaments play a role in axonal calibre as they help in movement of an impulse down the axon. Their activity depends on phosphorylation of neurofilaments.Mutations of neurofilaments causes Charcot-Marie-Tooth (CMT) disease. Accumulation of neurofilaments has been observed in many human neurological diseases like Alzheimer′s disease, progressive supranuclear palsy, diabetic neuropathy, and giant axonal neuropathy.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable