I7160

IMS2186

≥98% (HPLC), solid

• 別名: 3-[1-(3-ヒドロキシ-4-メトキシフェニル)-meth-(E)-イリデン]-6-メチル-クロマン-4-オン
• 実験式（ヒル表記法）: C₁₈H₁₆O₄
• CAS番号: 1031206-36-6
• 分子量: 296.32
• MDL番号: MFCD12912419
• UNSPSCコード: 12352200
• PubChem Substance ID: 329815315
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: solid
• 保管条件: desiccated
• 色: white to off-white
• 溶解性: DMSO: >20 mg/mL
• 保管温度: room temp
• SMILES記法: COc1ccc(cc1O)\C=C2/COc3ccc(C)cc3C2=O
• InChI: 1S/C18H16O4/c1-11-3-5-16-14(7-11)18(20)13(10-22-16)8-12-4-6-17(21-2)15(19)9-12/h3-9,19H,10H2,1-2H3/b13-8+
• InChI Key: BZCADTHMZLYKAR-MDWZMJQESA-N

詳細

生物化学的／生理学的作用

IMS2186 is an anti-proliferative and anti-angiogenic agent. Apparently IMS2186 blocks the cell cycle at G2 and inhibits the production of PGE2/TNF-α. IMS2186 inhibits cell growth in vitro in tumor cells, non-transformed fibroblasts, and retinal pigment epithelial cells. IMS2186 inhibits angiogenesis (IC₅₀ = 0.1 μM) and cell migration. Intraocular injection of IMS2186 could be a long-lasting effective treatment for CNV (choroidal neovascularization) in AMD (age-related macular degeneration) with a reduction in scarring and related visual loss.

安全性情報

• ピクトグラム: GHS09
• シグナルワード: Warning
• 危険有害性情報: H410
• 注意書き: P273 - P391 - P501
• 危険有害性の分類: Aquatic Acute 1 - Aquatic Chronic 1
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Gloves