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由来生物
mouse
結合体
FITC conjugate
抗体製品の状態
purified immunoglobulin
抗体製品タイプ
primary antibodies
クローン
hVIN-1, monoclonal
フォーム
buffered aqueous solution
分子量
antigen 116 kDa
交差性
frog, chicken, mouse, canine, human, bovine, rat, turkey
保管条件
protect from light
テクニック
direct immunofluorescence: 1:50 using methanol/acetone fixed cultured bovine MDBK cells
アイソタイプ
IgG1
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... VCL(7414)
mouse ... Vcl(22330)
rat ... Vcl(305679)
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特異性
細胞-細胞および細胞-基質間接触におけるビンキュリンを特異的に標識します。ヒトビンキュリンと強く反応します。平滑筋メタビンキュリンとの交差反応性が認められます。
免疫原
子宮から精製されたヒトビンキュリン。
アプリケーション
Monoclonal Anti-Vinculin-FITC antibody is suitable for immunofluorescence staining of fibroblasts cells to study the effects of nanofiber spatial organization on cell behaviors. It is also suitable for direct immunofluorescence at a dilution of 1:50 using methanol/acetone fixed cultured bovine MDBK cells.
生物化学的／生理学的作用
Vinculin is a cytoskeletal protein with molecular mass of ~116 kDa. Vinculin is closely associated with adhesive membrane areas, such as focal contacts, podosomes, or intercellular junctions of the zonula adherens type. It acts as a mediator in interactions of integrins and the actin cytoskeleton. It forms a bridge between integrins, receptors for ECM molecules on the cell surface and the F-actin cytoskeleton. It is associated with talin and α-actinin which directly connects with integrins. It has ability to bind α-catenin as well as the vasodilator stimulated phosphoprotein (VASP) in focal contact assembly.
物理的形状
0.01M PBS溶液 (pH 7.4, 1%BSA, 15mMアジ化ナトリウム含有)。
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
12 - Non Combustible Liquids
WGK
nwg
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
F7053-200UL:
F7053-VAR:
F7053-BULK:
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