A8849

α₂-アンチプラスミン ヒト血漿由来

lyophilized powder, ≥5 units/mg protein

• CAS番号: 138757-15-0
• MDL番号: MFCD00130471
• UNSPSCコード: 12352202
• NACRES: NA.77

特性

• 由来生物: human plasma
• 品質水準: 200
• 形状: lyophilized powder
• 比活性: ≥5 units/mg protein
• 包装: vial of ≥0.5 mg (Protein based on E1%/280 = 6.7)
• UniProtアクセッション番号: P08697
• 保管温度: −20°C
• 遺伝子情報: human ... SERPINF2(5345)

詳細

詳細

α2-Antiplasmin (α2AP) is a glycoprotein and a member of the serine protease inhibitor (serpin) family. The protein is mainly synthesized in the liver and found in the kidney and brain. The serpin peptidase inhibitor, clade F member 2 (SERPINF2) gene is mapped to human chromosome 17p13.3.

アプリケーション

α2-Antiplasmin from human plasma has been used as a protease inhibitor to treat human microvascular endothelial cells (HMEC-1) and demonstrate the role of factors responsible for endothelial cells detachment. It has also been used to study its effect on the release of proteolytic activity under reducing conditions in therapeutic human serum albumin-containing products with a new neoepitope endopeptidase immunoassay.

生物化学的／生理学的作用

α2-Antiplasmin (α2AP) is an antifibrinolytic protein and an important inhibitor of plasmin. α2AP mediates clot formation by covalently cross-linking with the glutamine and the lysine residue of fibrin clot via activated factor XIII (FXIIIa). This prevents the clot from extreme degradation by plasmin. An inborn insufficiency of α2AP results in an autosomal recessive condition leading to a rare bleeding disorder. The severity of the bleeding condition is defined by the individual′s genetic variation. Studies show lower levels of α2AP associated with disseminated intravascular coagulation (DIC) and thrombolytic therapy. Elevated levels of α2AP have been reported in a patient with ischemic stroke.

単位の定義

1 unitは、Val-Leu-Lys-p-ニトロアニリドを用い、37°C、pH7.2で、2 unitsのプラスミンの活性を50%低下させます。

物理的形状

ビス-トリス緩衝液と塩化ナトリウムを含む凍結乾燥粉末。

免責事項

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H315,H319,H335
• 注意書き: P261 - P305 + P351 + P338
• 危険有害性の分類: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Gloves