33894

クロトリマゾール

VETRANAL^®, analytical standard

• 別名: 1-(o-クロロ-α,α-ジフェニルベンジル)イミダゾール, 1-(o-クロロトリチル)イミダゾール, 1-[(2-クロロフェニル)ジフェニルメチル]-1H-イミダゾール
• 実験式（ヒル表記法）: C₂₂H₁₇ClN₂
• CAS番号: 23593-75-1
• 分子量: 344.84
• EC Number: 245-764-8
• MDL番号: MFCD00057220
• UNSPSCコード: 41116107
• PubChem Substance ID: 329754531
• NACRES: NA.24

特性

• グレード: analytical standard
• 製品種目: VETRANAL^®
• シェルフライフ: limited shelf life, expiry date on the label
• テクニック: HPLC: suitable; gas chromatography (GC): suitable
• 抗生物質活性スペクトル: fungi
• アプリケーション: agriculture; environmental
• フォーマット: neat
• 作用機序: protein synthesis | interferes
• SMILES記法: Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4ccnc4
• InChI: 1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H
• InChI Key: VNFPBHJOKIVQEB-UHFFFAOYSA-N

詳細

詳細

Clotrimazole, a non-toxic, systemic, imidazole derivative with broad-spectrum antimycotic activity, is primarily used in the treatment of oropharyngeal candidiasis.

Its mode of action involves the inhibition of ergosterol synthesis, which leads to structural and functional damage of the cell membrane.

アプリケーション

Clotrimazole may be used as a reference standard for the determination of the analyte in topical creams and ear drops by reversed-phase high-performance liquid chromatographic (RP-HPLC) method.

Clotrimazole may be used as an analytical reference standard for the determination of the analyte in:

• Milk samples using solid-phase extraction followed by high-performance liquid chromatography (SPE-HPLC).
• Environmental water samples using dispersive liquid-liquid microextraction followed by high-performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS).

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

法的情報

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS07,GHS09
• シグナルワード: Warning
• 危険有害性情報: H302,H315,H319,H410
• 注意書き: P264 - P270 - P273 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• 危険有害性の分類: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Gloves