22632

キニーネ 塩酸塩 二水和物

tested according to Ph. Eur.

• 別名: Chinini hydrochloridum, (8α, 9R)-6′-Methoxycinchonan-9-ol monohydrochloride dihydrate
• 実験式（ヒル表記法）: C₂₀H₂₄N₂O₂ · HCl · 2H₂O
• CAS番号: 6119-47-7
• 分子量: 396.91
• Beilstein: 6112655
• EC Number: 205-001-1
• MDL番号: MFCD00151248
• UNSPSCコード: 12352210
• PubChem Substance ID: 329752329
• NACRES: NA.25

特性

• 認証: USP/NF; tested according to Ph. Eur.
• 品質水準: 100
• フォーム: solid
• 溶解性: water: soluble 0.25 mg in 5 ml
• アプリケーション: pharmaceutical (small molecule)
• SMILES記法: O.O.Cl.COc1ccc2nccc([C@@H](O)[C@@H]3C[C@@H]4CCN3C[C@@H]4C=C)c2c1
• InChI: 1S/C20H24N2O2.ClH.2H2O/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;;;/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;1H;2*1H2/t13-,14-,19-,20+;;;/m0.../s1
• InChI Key: MPQKYZPYCSTMEI-FLZPLBAKSA-N

詳細

アプリケーション

Quinine hydrochloride dehydrate has been used for fluorescent in situ detection of quinine in cinchona bark using UV resonance raman spectroscopy. It has also been used as a actinometric system to measure the light-induced changes in ruthenium anticancer agent, NAMI-A.

生物化学的／生理学的作用

Quinine is a very effective anti-malarial treatment but is considered toxic for routine treatment due to the development of drug resistance in the malarial parasites. It acts as blood schizonticide.Quinine reportedly blocks the membrane conductance of potassium in enteric neurons.

安全性情報

• ピクトグラム: GHS08,GHS07
• シグナルワード: Danger
• 危険有害性情報: H302,H317,H334
• 注意書き: P261 - P264 - P272 - P280 - P301 + P312 - P302 + P352
• 危険有害性の分類: Acute Tox. 4 Oral - Resp. Sens. 1 - Skin Sens. 1
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Faceshields, Gloves