IL029

Interleukin-12 Protein, Recombinant human

The recombinant human Interleukin-12 protein (or IL-12 protein) is a potent regulator of cell mediated immune responses & it induces IFN-gamma production by NK & T cells.

• 別名: IL-12
• UNSPSCコード: 12352202
• eCl@ss: 32160405
• NACRES: NA.77

特性

• 由来生物: human
• 品質水準: 100
• リコンビナント: expressed in CHO cells
• アッセイ: >98% (SDS-PAGE and HPLC)
• 比活性: ≥1.0 x 10E6 U/mg
• メーカー／製品名: Chemicon^®
• テクニック: cell culture | mammalian: suitable
• 不純物: <0.1 ng/μg endotoxin (of IL-12; 1EU/μg)
• 入力: sample type hematopoietic stem cell(s)
• UniProtアクセッション番号: P29459; P29460
• 輸送温度: dry ice

詳細

詳細

Interleukin-12 (IL-12) is a potent regulator of cell mediated immune responses and it induces IFN-gamma production by NK and T cells. It is produced by activated monocytes/macrophage cells, B lymphocytes, and connective tissue type mast cells. Among its biological activities, IL-12 promotes the growth and activity of activated NK, CD4+ and CD8+ cells and induces the development of IFN-gamma producing Th1 cells. Human IL-12 is a disulfide linked heterodimeric protein with a molecular weight of 75 kDa comprised of disulfide-bonded 35 kDa (p35) and 40 kDa (p40) subunits.

Product Source: CHO cells (Chinese Hamster Ovarian cells)

アプリケーション

For most in vitro applications, IL-12 exerts its biological activity in the concentration range of 1.0 to 10.0 ng/mL.

生物化学的／生理学的作用

The ED50 as determined by the induction of IFN-g production from NK cells co-stimulated with IL-18 was ≤ 1.0 ng/mL

物理的形状

The sterile filtered solution was lyophilized from 0.5X PBS pH 7.2

保管および安定性

The lyophilized IL-12, though stable at room temperature, is best stored desiccated below 0°C. Reconstitute with sterile water to a concentration of 0.2 mg/mL. Reconstituted IL-12 should be stored in undiluted aliquots at -20°C for up to 6 months.

法的情報

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3