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Merck

524624

Sigma-Aldrich

Phosphatase Inhibitor Cocktail I

liquid, for the inhibition of alkaline phosphatases and serine/threonine protein phosphatases

別名:

Phosphatase inhibitor

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About This Item

UNSPSCコード:
12352200
NACRES:
NA.28

product name

Phosphatase Inhibitor Cocktail Set I, Phosphatase Inhibitor Cocktail Set I contains three inhibitors that will inhibit alkaline phosphatases as well as serine/threonine protein phosphatases such as PP1 and PP2A.

品質水準

形状

liquid

メーカー/製品名

Calbiochem®

保管条件

OK to freeze

輸送温度

ambient

保管温度

−20°C

詳細

A cocktail of three inhibitors that will inhibit alkaline phosphatases as well as serine/threonine protein phosphatases such as PP1 and PP2A. This product is provided as a set of five 1 ml vials. Each vial contains 1 ml phosphatase inhibitor cocktail solubilized in DMSO with the following components: Bromotetramisole oxalate (2.5 mM), Cantharidin (Cat. No. 210155; 500 µM), and Microcystin-LR (Cat. No. 475815; 500 nM).
A cocktail of three inhibitors that will inhibit alkaline phosphatases as well as serine/threonine protein phosphatases such as PP1 and PP2A. This product is provided as a set of five 1 ml vials. May be used with cell lysates and tissue extracts, including samples containing detergents. Each vial contains 1 ml phosphatase inhibitor cocktail solubilized in DMSO with the following components:

生物化学的/生理学的作用

Cell permeable: no
Primary Target
Alkaline phosphatases as well as serine/threonine protein phosphatases such as PP1 and PP2A
Product does not compete with ATP.
Reversible: no

物理的形状

In DMSO.

再構成

For long-term storage, aliquot and freeze (-20°C). Dilute 1:100 just prior to use.

法的情報

Not available for sale outside of the United States.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

保管分類コード

10 - Combustible liquids

WGK

WGK 1

引火点(°F)

188.6 °F - closed cup - (Dimethylsulfoxide)

引火点(℃)

87 °C - closed cup - (Dimethylsulfoxide)


適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

消防法

第4類:引火性液体
第三石油類
危険等級III
非水溶性液体

労働安全衛生法名称等を表示すべき危険物及び有害物

名称等を表示すべき危険物及び有害物

労働安全衛生法名称等を通知すべき危険物及び有害物

名称等を通知すべき危険物及び有害物

Jan Code

524624-1.0ML:
524624-1SML:
524624-1SET:


試験成績書(COA)

製品のロット番号・バッチ番号を入力して、試験成績書(COA) を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。

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An Phu Tran Nguyen et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(29), 17296-17307 (2020-07-08)
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of late-onset, autosomal-dominant familial Parkinson's disease (PD). LRRK2 functions as both a kinase and GTPase, and PD-linked mutations are known to influence both enzymatic activities. While PD-linked LRRK2
Agnes S Zybura et al.
The Journal of biological chemistry, 295(33), 11845-11865 (2020-07-03)
Nav1.6 is the primary voltage-gated sodium channel isoform expressed in mature axon initial segments and nodes, making it critical for initiation and propagation of neuronal impulses. Thus, Nav1.6 modulation and dysfunction may have profound effects on input-output properties of neurons
Rama K Mishra et al.
Chemical biology & drug design, 94(4), 1813-1823 (2019-07-02)
Mnk kinases (Mnk1 and 2) are downstream effectors of Map kinase pathways and regulate phosphorylation of eukaryotic initiation factor 4E. Engagement of the Mnk pathway is critical in acute myeloid leukemia (AML) leukemogenesis and Mnk inhibitors have potent antileukemic properties
Hajime Maeda et al.
Respiratory research, 23(1), 340-340 (2022-12-11)
Premature infants, subjected to supplemental oxygen and mechanical ventilation, may develop bronchopulmonary dysplasia, a chronic lung disease characterized by alveolar dysplasia and impaired vascularization. We and others have shown that hyperoxia causes senescence in cultured lung epithelial cells and fibroblasts.
David Shechter et al.
Nature protocols, 2(6), 1445-1457 (2007-06-05)
Histone proteins are the major protein components of chromatin, the physiologically relevant form of the genome (or epigenome) in all eukaryotic cells. Chromatin is the substrate of many biological processes, such as gene regulation and transcription, replication, mitosis and apoptosis.

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