924075

NHS ester-a-TCO

• 別名: (E)-N-Hydroxysuccinyl 2-(1-ax-hydroxycyclooct-4-en-1-yl)acetate, 2,5-Dioxopyrrolidin-1-yl (R,E)-2-(1-hydroxycyclooct-4-en-1-yl)acetate, Amine-reactive axial 5-hydroxy-trans-cyclooctene
• 実験式（ヒル表記法）: C₁₄H₁₉NO₅
• 分子量: 281.30
• UNSPSCコード: 12352108
• NACRES: NA.22

特性

• 反応適合性: reaction type: click chemistry; reactivity: amine reactive; reagent type: chemical modification reagent; reagent type: cross-linking reagent
• 品質水準: 100
• 官能基: NHS ester
• 保管温度: −20°C
• SMILES記法: O[C@@]1(CC(ON2C(CCC2=O)=O)=O)CC/C=C/CCC1

詳細

アプリケーション

NHS ester-a-TCO is an axial trans-cyclooctene (a-TCO) for bioconjugation and protein labeling. NHS ester-a-TCO has an amine-reactive NHS ester, and the a-TCO reacts rapidly with tetrazines through Diels–Alder reactions, a type of bioorthogonal, copper-free click chemistry. As demonstrated by the Joe Fox lab in Pigga, et al, a-TCOs are more reactive and hydrophilic than standard TCOs, providing favorable physiochemical properties for live-cell and in vivo labeling.

Other new a-TCOs:

• TAMRA-a-TCO (924083)
• Alkyne-a-TCO (924091)
• Amine-a-TCO (924113)

その他情報

General, Divergent Platform for Diastereoselective Synthesis of trans-Cyclooctenes with High Reactivity and Favorable Physiochemical Properties

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable