909998

2-(2-((7-(tert-Butoxy)-7-oxoheptyl)oxy)ethoxy)acetic acid

≥95%

• 別名: 2-2-6 PROTAC^® linker, Bifunctional linker, OtBu-PEG₂-acid
• 実験式（ヒル表記法）: C₁₅H₂₈O₆
• 分子量: 304.38
• UNSPSCコード: 12352200

特性

• アッセイ: ≥95%
• 形状: liquid
• 反応適合性: reagent type: linker
• 官能基: carboxylic acid; ester
• 保管温度: 2-8°C
• SMILES記法: CC(C)(OC(CCCCCCOCCOCC(O)=O)=O)C

詳細

アプリケーション

This heterobifunctional, PEGylated crosslinker 2-(2-((7-(tert-butoxy)-7-oxoheptyl)oxy)ethoxy)acetic acid features a carboxyl group at one end and a t-butyl protected carboxylic acid at the other and exhibits both hydrophobic and hydrophilic moieties for use in biological applications. The linker can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation where the linker region is referred to as 2-2-6.

その他情報

Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

法的情報

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable