910023

3,6,9,12,15,18-Hexaoxahexacos-25-ynoic acid

• 別名: 2-2-2-2-2-2-6 PROTAC^® linker, Alkyne-PEG₆-acid, Bifunctional linker
• 実験式（ヒル表記法）: C₂₀H₃₆O₈
• 分子量: 404.50
• UNSPSCコード: 12352106

特性

• 形状: liquid
• 反応適合性: reagent type: linker
• 官能基: alkyne; carboxylic acid
• 保管温度: 2-8°C
• SMILES記法: OC(COCCOCCOCCOCCOCCOCCCCCCC#C)=O

詳細

アプリケーション

This heterobifunctional, PEGylated crosslinker 3,6,9,12,15,18-hexaoxahexacos-25-ynoic acid features a carboxyl group at one end and an alkyne at the other and exhibits both hydrophobic and hydrophilic moieties for use in biological applications. This alkyne-PEG₆-acid linker can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation where the linker region is referred to as 2-2-2-2-2-2-6.

その他情報

Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL

Technology Spotlight: Partial PROTACs for Targeted Protein Degradation

法的情報

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable