Passa al contenuto
Merck
Tutte le immagini(1)

Key Documents

View All Documentation

C6643

Sigma-Aldrich

Clofibrate

liquid

Sinonimo/i:

2-(4-Chlorophenoxy)-2-methylpropionic acid ethyl ester, Ethyl 2-(4-chlorophenoxy)-2-methylpropionate, Ethyl 2-(4-chlorophenoxy)isobutyrate

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
Tutte le immagini(1)

About This Item

Formula empirica (notazione di Hill):
C12H15ClO3
Numero CAS:
637-07-0
Peso molecolare:
242.70
Beilstein:
1913459
Numero CE:
211-277-4
Numero MDL:
MFCD00000615
Codice UNSPSC:
12352200
ID PubChem:
24278085
NACRES:
NA.77

Forma fisica

liquid

Colore

clear colorless

Densità

1.14 g/mL at 25 °C (lit.)

Ideatore

Wyeth

Temperatura di conservazione

2-8°C

Stringa SMILE

CCOC(=O)C(C)(C)Oc1ccc(Cl)cc1

InChI

1S/C12H15ClO3/c1-4-15-11(14)12(2,3)16-10-7-5-9(13)6-8-10/h5-8H,4H2,1-3H3
KNHUKKLJHYUCFP-UHFFFAOYSA-N

Informazioni sul gene

human ... PPARA(5465)
mouse ... Ppara(19013)

Cerchi prodotti simili? Visita Guida al confronto tra prodotti

Applicazioni

Clofibrate has been used:
  • as a quinolinate phosphoribosyltransferase (QPRT) agonist to study its effects on hepatitis C virus (HCV) infection
  • as peroxisome proliferated activated receptor (PPAR) agonist to study its effects on autophagy in rat liver cells
  • as a hepatotoxicant to study its effects on gene expression in primary rat hepatocytes

Azioni biochim/fisiol

Clofibrate is a peroxisome proliferated activated receptor α (PPARα) agonist. It is a fibric acid derivative and has a therapeutic effect on hypertriglyceridemia and hyperlipoproteinemia type III. Clofibrate participates in lowering the very-low-density lipoprotein (VLDL) and cholesterol levels in hyperlipoproteinemia type III patients. It facilitates the decrease of total serum bilirubin concentration in Gilbert′s syndrome.

Caratteristiche e vantaggi

This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Confezionamento

Bottomless glass bottle. Contents are inside inserted fused cone.

Pittogrammi

CorrosionExclamation mark
GHS05,GHS07

Avvertenze

Danger

Indicazioni di pericolo

H302,H315,H318,H335

Classi di pericolo

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

235.4 °F - closed cup

Punto d’infiammabilità (°C)

113 °C - closed cup

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

I clienti hanno visto anche

Slide 1 of 7

1 of 7

4,4′-DDT solution certified reference material, 5000 μg/mL in methanol

Supelco

40124

4,4′-DDT solution

17-Octadecynoic acid ≥95% (GC)

Sigma-Aldrich

O8382

17-Octadecynoic acid

Cimetidine

Sigma-Aldrich

C4522

Cimetidine

Tolbutamide analytical standard

Supelco

T0891

Tolbutamide

9-cis-Retinoic acid ≥98% (HPLC)

Sigma-Aldrich

R4643

9-cis-Retinoic acid

N-Nitrosodiethylamine ISOPAC®

Sigma-Aldrich

N0258

N-Nitrosodiethylamine

AICAR ≥98% (HPLC), powder

Sigma-Aldrich

A9978

AICAR

Drug treatment of lipid disorders.
R H Knopp
The New England journal of medicine, 341(7), 498-511 (1999-08-12)
K Nadira De Abrew et al.
Toxicology, 328, 29-39 (2014-12-06)
High-content data have the potential to inform mechanism of action for toxicants. However, most data to support this notion have been generated in vivo. Because many cell lines and primary cells maintain a differentiated cell phenotype, it is possible that
Toshio Morikawa et al.
Journal of natural products, 71(5), 828-835 (2008-03-28)
The methanolic extract and its saponin fraction (methanol-eluted fraction) of the flowers of Bellis perennis were found to suppress serum triglyceride elevation in olive oil-treated mice. From the saponin fraction, seven new triterpene saponins, perennisosides I (1), II (2), III
Masayuki Yoshikawa et al.
Journal of natural products, 68(9), 1360-1365 (2005-09-27)
The methanolic extract and its n-butanol-soluble fraction from the flowers of the tea plant (Camellia sinensis) were found to suppress serum triglyceride elevation in olive oil-treated mice. From the n-butanol-soluble fraction, three new acylated oleanane-type triterpene oligoglycosides, floratheasaponins A-C (1-3)
Sara Chuang et al.
Journal of medicinal chemistry, 52(17), 5344-5355 (2009-08-12)
Liver-fatty acid binding protein (L-FABP) is found in high levels in enterocytes and is involved in cytosolic solubilization of fatty acids. In addition, L-FABP has been shown to bind endogenous and exogenous lipophilic compounds, suggesting that it may also play
Visualizza tutti i documenti correlati

Articoli

Cholesterol Biosynthesis Regulation

The amount of cholesterol that is synthesized in the liver is tightly regulated by dietary cholesterol levels. LDL receptors regulate the cellular transport of lipid rich low density lipoprotein (LDL) particles.

Antilipemic Agents

Randomized controlled clinical studies have suggested 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) are effective in both primary and secondary prevention of cardiovascular disease (CVD) events.

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.