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N0258

Sigma-Aldrich

N-Nitrosodiethylamine

ISOPAC®

Sinonimo/i:

Diethylnitrosamine

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About This Item

Formula condensata:
(C2H5)2NNO
Numero CAS:
55-18-5
Peso molecolare:
102.14
Beilstein:
1744991
Numero CE:
200-226-1
Numero MDL:
MFCD00013890
Codice UNSPSC:
12352116
ID PubChem:
24897417
NACRES:
NA.25

Stato

liquid

P. ebollizione

177 °C (lit.)

Densità

0.95 g/mL (lit.)

Stringa SMILE

CCN(CC)N=O

InChI

1S/C4H10N2O/c1-3-6(4-2)5-7/h3-4H2,1-2H3
WBNQDOYYEUMPFS-UHFFFAOYSA-N

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Applicazioni

N-Nitrosodiethylamine (NDEA) has been used as a hepatocarcinogen/DNA damaging agent. It has been used as a calibration standard for gas–liquid chromatography.

Azioni biochim/fisiol

N-Nitrosodiethylamine (NDEA) is a potent hepatocarcinogenic dialkylnitrosoamine. It is mainly present in tobacco smoke, water, cheddar cheese, cured, fried meals and many alcoholic beverages. NDEA is responsible for the changes in the nuclear enzymes associated with DNA repair/replication. It results in various tumors in all animal species. The main target organs are the nasal cavity, trachea, lung, esophagus and liver.

Confezionamento

Packaged in a 100 mL serum bottle with silicon/PTFE septum and aluminum tear seal.

Avvertenza

Injecting any compatible solvent permits preparation of any desired strength solution without exposure.

Ricostituzione

Dissolving the contents in 100 mL of solvent yields a 1% solution.

Note legali

Isopac is a registered trademark of Merck KGaA, Darmstadt, Germany

ISOPAC

N° Catalogo
Descrizione
Determinazione del prezzo

N0756

N-Nitrosodiethylamine, liquid

Pittogrammi

Skull and crossbonesHealth hazard
GHS06,GHS08

Avvertenze

Danger

Indicazioni di pericolo

H301,H350,H412

Classi di pericolo

Acute Tox. 3 Oral - Aquatic Chronic 3 - Carc. 1B

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Certificati d'analisi (COA)

Lot/Batch Number
MKCN8521
MKCM0585
MKCK9777
MKCK9778
MKCJ7568

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Proteomic profiling of expression of proteasomal subunits from livers of mice treated with diethylnitrosamine.
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Chemopreventive effect of hydroethanolic extract of Euphorbia neriifolia leaves against DENA-induced renal carcinogenesis in mice.
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The detection of DNA adducts (risk factors for DNA damage). A method for genomic DNA, the results and some effects of nutritional intervention.
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Articoli

DNA Damage and Repair

DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.

Carcinogenesis and Epigenetics

Carcinogenesis and Epigenetics

Protocolli

US EPA Method 8270 (Appendix IX): GC Analysis of Semivolatiles on Equity®-5 (30 m x 0.25 mm I.D., 0.50 μm)

US EPA Method 8270 (Appendix IX): GC Analysis of Semivolatiles on Equity®-5 (30 m x 0.25 mm I.D., 0.50 μm)

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