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N7510

Sigma-Aldrich

尼卡地平 盐酸盐

powder, ≥98%

别名:

1,4-二氢-2,6-二甲基-4-（3-硝基苯基）-3,5-吡啶二甲酸甲基 2- [甲基（苯甲基）氨基] 乙酯 盐酸盐, YC-93

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About This Item

经验公式（希尔记法）:
C26H29N3O6 · HCl
CAS号:
54527-84-3
分子量:
515.99
EC號碼:
259-198-4
MDL號碼:
MFCD00057327
分類程式碼代碼:
12352200
PubChem物質ID:
24277856
NACRES:
NA.77

品質等級

100

化驗

≥98%

形狀

powder

顏色

yellow

溶解度

DMSO: ~1 mg/mL
0.1 M NaOH: insoluble
H2O: slightly soluble
methanol: soluble

起源

EKR Therapeutics

儲存溫度

2-8°C

SMILES 字串

Cl[H].COC(=O)C1=C(C)NC(C)=C(C1c2cccc(c2)[N+]([O-])=O)C(=O)OCCN(C)Cc3ccccc3

InChI

1S/C26H29N3O6.ClH/c1-17-22(25(30)34-4)24(20-11-8-12-21(15-20)29(32)33)23(18(2)27-17)26(31)35-14-13-28(3)16-19-9-6-5-7-10-19;/h5-12,15,24,27H,13-14,16H2,1-4H3;1H

InChI 密鑰

AIKVCUNQWYTVTO-UHFFFAOYSA-N

基因資訊

human ... CACNA1C(775) , CACNA1D(776) , CACNA1F(778) , CACNA1S(779)

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生化／生理作用

阻断 L 型电压依赖性钙通道；抗高血压药。

特點和優勢

该化合物由 EKR Therapeutics 开发 。要浏览其他制药公司开发的化合物列表批准的药物/候选药物的列表， 点击这里 。

象形圖

Skull and crossbones
GHS06

訊號詞

Danger

危險聲明

H301 + H311 + H331

危險分類

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

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Prasanna P K M Gamage et al.
Journal of cellular and molecular medicine, 22(10), 5160-5164 (2018-07-27)
Ageing is associated with impaired neuromuscular function of the terminal gastrointestinal (GI) tract, which can result in chronic constipation, faecal impaction and incontinence. Interstitial cells of cajal (ICC) play an important role in regulation of intestinal smooth muscle contraction. However
S Thellung et al.
Neurobiology of disease, 7(4), 299-309 (2000-08-31)
Prion diseases are neurodegenerative pathologies characterized by the accumulation, in the brain, of altered forms of the prion protein (PrP), named PrP(Sc). A synthetic peptide homologous to residues 106-126 of PrP (PrP106-126) was reported to maintain the neurodegenerative characteristics of
I Japelj et al.
European journal of pharmacology, 369(1), 43-47 (1999-04-16)
The qualitative and quantitative effects of the (+)-S and (-)-R enantiomers and of the racemic mixture of the Ca2+ channel antagonist, nicardipine, were compared on the isolated porcine coronary artery with intact and removed endothelium. All three forms of nicardipine
E M Fitzgerald
The Journal of physiology, 527 Pt 3, 433-444 (2000-09-16)
The small G-protein Ras, a critical component in the signalling pathways regulating cell growth, is involved in the tonic upregulation of voltage-dependent calcium channels (VDCCs) in rat sensory neurones. To investigate which downstream effector(s) of Ras is involved in this
T Matsuda et al.
General pharmacology, 33(2), 115-125 (1999-08-26)
The effects of nicardipine and bupivacaine on early afterdepolarizations (EADs) were investigated in rabbit sinoatrial (SA) nodes using the conventional microelectrode technique. In a nominally Ca2+ -free, Mg2+ -free solution, addition of 0.5 mM Sr2+ produced EADs following prolongation of
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